Trypanosoma cruzi Infection and Nuclear Factor Kappa B Activation Prevent Apoptosis in Cardiac Cells

Christine A Petersen; Katherine A Krumholz; John Carmen; Anthony P Sinai; Barbara A Burleigh

doi:10.1128/IAI.74.3.1580-1587.2006

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Trypanosoma cruzi Infection and Nuclear Factor Kappa B Activation Prevent Apoptosis in Cardiac Cells

Journal article

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Trypanosoma cruzi Infection and Nuclear Factor Kappa B Activation Prevent Apoptosis in Cardiac Cells

Christine A Petersen, Katherine A Krumholz, John Carmen, Anthony P Sinai and Barbara A Burleigh

Infection and immunity, Vol.74(3), pp.1580-1587

03/2006

DOI: 10.1128/IAI.74.3.1580-1587.2006

PMCID: PMC1418648

PMID: 16495529

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Abstract

Studies of cardiac pathology and heart failure have implicated cardiomyocyte apoptosis as a critical determinant of disease. Recent evidence indicates that the intracellular protozoan parasite Trypanosoma cruzi, which causes heart disease in chronically infected individuals, impinges on host apoptotic pathways in a cell type-dependent manner. T. cruzi infection of isolated neuronal cells and cardiomyocytes protects against apoptotic cell death, whereas apoptosis is triggered in T cells in T. cruzi-infected animals. In this study, we demonstrate that the ability of T. cruzi to protect cardiac cells in vitro from apoptosis triggered by a combination of tumor necrosis factor alpha and serum reduction correlates with the presence of intracellular parasites and involves activation of host cell NF-[kappa]B. We further demonstrate that the apoptotic block diminishes activation of caspase 3. The ability of T. cruzi to prevent apoptosis of infected cardiomyocytes is likely to play an important role in establishment of persistent infection in the heart while minimizing potential damage and remodeling that is associated with cardiomyocyte apoptosis in cardiovascular disease.

Details

Title: Subtitle: Trypanosoma cruzi Infection and Nuclear Factor Kappa B Activation Prevent Apoptosis in Cardiac Cells
Creators: Christine A Petersen
Katherine A Krumholz
John Carmen
Anthony P Sinai
Barbara A Burleigh
Resource Type: Journal article
Publication Details: Infection and immunity, Vol.74(3), pp.1580-1587
DOI: 10.1128/IAI.74.3.1580-1587.2006
PMID: 16495529
PMCID: PMC1418648
NLM abbreviation: Infect Immun
ISSN: 0019-9567
eISSN: 1098-5522
Publisher: American Society for Microbiology
Language: English
Date published: 03/2006
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9984214691502771

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