Journal article
Tubal Factor Infertility and Perinatal Risk After Assisted Reproductive Technology
Obstetrics and gynecology (New York. 1953), Vol.121(6), pp.1263-1271
06/01/2013
DOI: 10.1097/AOG.0b013e31829006d9
PMCID: PMC4292839
PMID: 23812461
Abstract
OBJECTIVE: To assess trends of tubal factor infertility and to evaluate risk of miscarriage and delivery of preterm or low birth weight (LBW) neonates among women with tubal factor infertility using assisted reproductive technology (ART).
METHODS: We assessed trends of tubal factor infertility among all fresh and frozen, donor, and nondonor ART cycles performed annually in the United States between 2000 and 2010 (N=1,418,774) using the National ART Surveillance System. The data set was then limited to fresh, nondonor in vitro fertilization cycles resulting in pregnancy to compare perinatal outcomes for cycles associated with tubal compared with male factor infertility. We performed bivariate and multivariable analyses controlling for maternal characteristics and calculated adjusted risk ratios (RRs) and 95% confidence intervals (CI).
RESULTS: The percentage of ART cycles associated with tubal factor infertility diagnoses decreased from 2000 to 2010 (26.02-14.81%). Compared with male factor infertility, tubal factor portended an increased risk of miscarriage (14.0% compared with 12.7%, adjusted RR 1.08, 95% CI 1.04-1.12); risk was increased for both early and late miscarriage. Singleton neonates born to women with tubal factor infertility had an increased risk of preterm birth (15.8% compared with 11.6%, adjusted RR 1.27, 95% CI 1.20-1.34) and LBW (10.9% compared with 8.5%, adjusted RR 1.28, 95% CI 1.20-1.36). Significant increases in risk persisted for early and late preterm delivery and very low and moderately LBW delivery. A significantly elevated risk was also detected for twin, but not triplet, pregnancies.
CONCLUSION: Tubal factor infertility, which is decreasing in prevalence in the United States, is associated with an increased risk of miscarriage, preterm birth, and LBW delivery as compared with couples with male factor infertility using ART.
Details
- Title: Subtitle
- Tubal Factor Infertility and Perinatal Risk After Assisted Reproductive Technology
- Creators
- Jennifer F. Kawwass - Centers for Disease Control and PreventionSara CrawfordDmitry M. KissinDonna R. SessionSheree BouletDenise J. Jamieson
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.121(6), pp.1263-1271
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/AOG.0b013e31829006d9
- PMID
- 23812461
- PMCID
- PMC4292839
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Number of pages
- 9
- Grant note
- CC999999 / Intramural CDC HHS
- Language
- English
- Date published
- 06/01/2013
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446438502771
Metrics
2 Record Views