Journal article
Tumor Necrosis Factor-α Modulates Cerebral Aneurysm Formation and Rupture
Translational stroke research, Vol.5(2), pp.269-277
04/2014
DOI: 10.1007/s12975-013-0287-9
PMID: 24323710
Abstract
Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment of macrophages, activation of chemotactic cytokines, upregulation of matrix remodeling genes, production of free radicals leading to oxidative stress, and ultimately cellular apoptosis. Recent studies have indicated that TNF-α may be a potential target for the development of novel medical therapies, but additional experimental data is needed to clarify the intricacies of TNF-α activation and its critical downstream targets in cerebral aneurysms. This review provides an update on the mechanisms underlying TNF-α-induced molecular modulation in cerebral aneurysms.
Details
- Title: Subtitle
- Tumor Necrosis Factor-α Modulates Cerebral Aneurysm Formation and Rupture
- Creators
- Robert Starke - Department of Neurological Surgery University of Virginia Charlottesville VA USADaniel Raper - Department of Neurological Surgery University of Virginia Charlottesville VA USADale Ding - Department of Neurological Surgery University of Virginia Charlottesville VA USANohra Chalouhi - Department of Neurosurgery Thomas Jefferson University Philadelphia PA USAGary Owens - Department of Molecular Physiology and Biophysics Robert M. Berne Cardiovascular Research Center Charlottesville VA USADavid Hasan - Department of Neurological Surgery University of Iowa Iowa City IA USARicky Medel - Department of Neurological Surgery Tulane University 131 S. Robertson St., Suite 1300 New Orleans LA USAAaron Dumont - Department of Neurological Surgery Tulane University 131 S. Robertson St., Suite 1300 New Orleans LA USA
- Resource Type
- Journal article
- Publication Details
- Translational stroke research, Vol.5(2), pp.269-277
- Publisher
- Springer US; Boston
- DOI
- 10.1007/s12975-013-0287-9
- PMID
- 24323710
- ISSN
- 1868-4483
- eISSN
- 1868-601X
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040393502771
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