Journal article
Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women's Health Study
Modern pathology, Vol.29(5), pp.516-527
05/2016
DOI: 10.1038/modpathol.2016.42
PMCID: PMC4848192
PMID: 26916075
Abstract
The role of the innate immune response in colorectal cancer is understudied. We examined the survival of colorectal cancer patients in relation to eosinophils, innate immune cells, infiltrating the tumor. Tissue microarrays were constructed from paraffin-embedded tumor tissues collected between 1986 and 2002 from 441 post-menopausal women diagnosed with colorectal cancer in the Iowa Women's Health Study. Tissue microarrays were stained with an eosinophil peroxidase antibody. Eosinophils in epithelial and stromal tissues within the tumor (called epithelial and stromal eosinophils, hereafter) were counted and scored into three and four categories, respectively. In addition, the degree of eosinophil degranulation (across epithelial and stromal tissues combined) was quantified and similarly categorized. We used Cox regression to estimate the hazard ratios and 95% confidence interval for all-cause and colorectal cancer death during 5-year follow-up after diagnosis and during follow-up through 2011 ('total follow-up'). The hazard ratios associated with eosinophil scores were adjusted for age of diagnosis, SEER (Surveillance, Epidemiology, and End Results) stage, tumor grade, body mass, and smoking history. High tumor stromal eosinophil score was inversely correlated with age and stage, and was associated with a decreased risk for all-cause and colorectal cancer death: hazard ratios (95% confidence intervals) were 0.61 (0.36-1.02; P-trend=0.02) and 0.48 (0.24-0.93; P-trend=0.01), respectively, during the 5-year follow-up for the highest vs lowest category. The inverse associations also existed for total follow-up for all-cause and colorectal cancer death for the highest vs lowest stromal eosinophil score: hazard ratios (95% confidence intervals) were 0.72 (0.48-1.08; P-trend=0.04) and 0.61 (0.34-1.12; P-trend=0.04), respectively. Further adjustment for treatment, comorbidities, additional lifestyle factors, tumor location, or molecular markers did not markedly change the associations, while adjustment for cytotoxic T cells slightly attenuated all associations. The infiltration of tumors with eosinophils, especially in stromal tissue, may be an important prognostic factor in colorectal cancer.
Details
- Title: Subtitle
- Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women's Health Study
- Creators
- Anna E Prizment - University of Minnesota Masonic Cancer Center, Minneapolis, MN, USARobert A Vierkant - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USAThomas C Smyrk - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USALori S Tillmans - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USAJames J Lee - Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, USAP Sriramarao - College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, USAHeather H Nelson - University of Minnesota Masonic Cancer Center, Minneapolis, MN, USACharles F Lynch - Department of Epidemiology, University of Iowa, Iowa City, IA, USAStephen N Thibodeau - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USATimothy R Church - Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN, USAJames R Cerhan - Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USAKristin E Anderson - University of Minnesota Masonic Cancer Center, Minneapolis, MN, USAPaul J Limburg - Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
- Resource Type
- Journal article
- Publication Details
- Modern pathology, Vol.29(5), pp.516-527
- Publisher
- United States
- DOI
- 10.1038/modpathol.2016.42
- PMID
- 26916075
- PMCID
- PMC4848192
- ISSN
- 1530-0285
- eISSN
- 1530-0285
- Grant note
- R01 CA107333 / NCI NIH HHS HHSN261201000032C / NCI NIH HHS UL1 TR000114 / NCATS NIH HHS P30 CA086862 / NCI NIH HHS R01 CA039742 / NCI NIH HHS
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995017002771
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