Tumor grade of clear cell renal cell carcinoma assessed by contrast-enhanced computed tomography

Kousei Ishigami; Leandro V Leite; Marius G Pakalniskis; Daniel K Lee; Danniele G Holanda; David M Kuehn

doi:10.1186/2193-1801-3-694

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Tumor grade of clear cell renal cell carcinoma assessed by contrast-enhanced computed tomography

Journal article

Open access

Peer reviewed

Tumor grade of clear cell renal cell carcinoma assessed by contrast-enhanced computed tomography

Kousei Ishigami, Leandro V Leite, Marius G Pakalniskis, Daniel K Lee, Danniele G Holanda and David M Kuehn

SpringerPlus, Vol.3(1), pp.1-7

12/2014

DOI: 10.1186/2193-1801-3-694

PMCID: PMC4363222

PMID: 25806147

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Abstract

The purpose of this study was to clarify the association between CT findings and Fuhrman grade of clear cell renal cell carcinoma (ccRCC). The study group consisted of 214 surgically proven ccRCC in 214 patients. Contrast-enhanced CT studies were retrospectively assessed for tumor size, cystic versus solid, calcification, heterogeneity of lesions, percentage of non-enhancing (necrotic) areas, and growth pattern. CT findings and Fuhrman grade were compared. Nineteen of 22 (86.4%) cystic ccRCC were low grade (Fuhrman grades 1-2). There was no significant correlation between tumor size and grade in cystic ccRCC (P = 0.43). In predominantly solid ccRCC, there was significant correlation between tumor size and grade (P < 0.0001). Thirty-eight of 43 (88.4%) infiltrative ccRCC were high grade (Fuhrman grades 3-4). Logistic regression showed tumor size and infiltrative growth were significantly associated with grades 3-4 (P = 0.00083 and P = 0.0059). Cystic ccRCC tends to be low grade. Infiltrative growth and larger tumor size may increase the likelihood of high grade ccRCC.

Computed Tomography

Clear cell renal cell carcinoma

Growth pattern

Research

Cystic renal cell carcinoma

Fuhrman grade

Details

Title: Subtitle: Tumor grade of clear cell renal cell carcinoma assessed by contrast-enhanced computed tomography
Creators: Kousei Ishigami - Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA
Leandro V Leite - Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA
Marius G Pakalniskis - Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA
Daniel K Lee - University of Iowa
Danniele G Holanda - Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA
David M Kuehn - Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: SpringerPlus, Vol.3(1), pp.1-7
DOI: 10.1186/2193-1801-3-694
PMID: 25806147
PMCID: PMC4363222
NLM abbreviation: Springerplus
ISSN: 2193-1801
eISSN: 2193-1801
Publisher: Springer International Publishing; Cham
Language: English
Date published: 12/2014
Academic Unit: Radiology; Pathology; Urology
Record Identifier: 9984046912902771

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