Journal article
Tumor necrosis factor is required for RANTES-induced astrocyte monocyte chemoattractant protein-1 production
Glia, Vol.43(2), pp.119-127
08/2003
DOI: 10.1002/glia.10231
PMID: 12838504
Abstract
Astrocytes respond to stimulation with the chemokine RANTES (regulated on activation, normal T cell expressed) by production of a series of cytokines and chemokines, including tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1). In the present study we demonstrate that RANTES induces TNF, which in turn stimulates subsequent production of MCP-1. TNF-R1 (p55) serves as the principal receptor responsible for MCP-1 synthesis. The results define an astrocyte proinflammatory cascade that amplifies synthesis of proinflammatory mediators. The implications of these findings to inflammatory diseases of the central nervous system are discussed. © 2003 Wiley-Liss, Inc.
Details
- Title: Subtitle
- Tumor necrosis factor is required for RANTES-induced astrocyte monocyte chemoattractant protein-1 production
- Creators
- Yi Luo - Harvard UniversityMichael A. Berman - Harvard UniversitySara R. Abromson-Leeman - Harvard UniversityMartin E. Dorf - Harvard University
- Resource Type
- Journal article
- Publication Details
- Glia, Vol.43(2), pp.119-127
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/glia.10231
- PMID
- 12838504
- ISSN
- 0894-1491
- eISSN
- 1098-1136
- Number of pages
- 9
- Language
- English
- Date published
- 08/2003
- Academic Unit
- Urology
- Record Identifier
- 9984319970102771
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