Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia

T H Wassink; R R Crowe; N C Andreasen

doi:10.1038/sj.mp.4000807

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Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia

Journal article

Peer reviewed

Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia

T H Wassink, R R Crowe and N C Andreasen

Molecular psychiatry, Vol.5(6), pp.678-682

11/2000

DOI: 10.1038/sj.mp.4000807

PMID: 11126399

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Abstract

A growing body of research suggests the involvement of immune system factors in central nervous system development and in pathophysiology related to schizophrenia.(1,2) We therefore investigated the Tumor Necrosis Factor Receptor-II (TNF-RII), a TNFalpha receptor expressed in fetal brain, as a candidate disease gene for schizophrenia. We also investigated the relationship between TNF-RII and adult brain morphology. The study sample consisted of 140 probands diagnosed with schizophrenia or schizophreniform disorder, 197 parents of the probands (a subset of which formed 62 proband-parent trios), and 46 psychiatrically normal control subjects. A bi-allelic TNF-RII polymorphism was examined for evidence of association, with none being found between this polymorphism and schizophrenia. Subjects with schizophrenia homozygous for allele 1, however, had larger ventricles and smaller frontal lobes than subjects with at least one copy of allele 2. On follow-up testing, they also had an earlier, less variable age of onset for their illness. We found no support, therefore, for TNF-RII as a disease susceptibility gene for schizophrenia. The gene may, however, modify phenotypic aspects of the disease such as brain morphology and age of onset of illness.

Genetic Predisposition to Disease

Gene Frequency

Humans

Family Health

Male

Schizophrenia - pathology

Antigens, CD - genetics

Linkage Disequilibrium

Polymorphism, Genetic

Phenotype

Psychotic Disorders - genetics

Schizophrenia - genetics

Receptors, Tumor Necrosis Factor, Type II

Age of Onset

Psychotic Disorders - pathology

Brain - pathology

Female

Receptors, Tumor Necrosis Factor - genetics

Details

Title: Subtitle: Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia
Creators: T H Wassink - Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242, USA. thomas-wassink@uiowa.edu
R R Crowe
N C Andreasen
Resource Type: Journal article
Publication Details: Molecular psychiatry, Vol.5(6), pp.678-682
DOI: 10.1038/sj.mp.4000807
PMID: 11126399
NLM abbreviation: Mol Psychiatry
ISSN: 1359-4184
eISSN: 1476-5578
Publisher: England
Grant note: MH43212 / NIMH NIH HHS MH00735 / NIMH NIH HHS MH-31593 / NIMH NIH HHS
Language: English
Date published: 11/2000
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984003952802771

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