Journal article
Tunable Bifunctional Silyl Ether Cross-Linkers for the Design of Acid-Sensitive Biomaterials
Journal of the American Chemical Society, Vol.132(50), pp.17928-17932
12/22/2010
DOI: 10.1021/ja108568g
PMCID: PMC3097112
PMID: 21105720
Abstract
Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of biomaterials provide precise control over the rate of degradation and the release rate of entrapped cargo and yield a material that is intrinsically nontoxic. In this work, we designed nontoxic acid-sensitive biomaterials based on silyl ether chemistry. A host of silyl ether cross-linkers were synthesized and molded into relevant medical devices, including Trojan horse particles, sutures, and stents. The resulting devices were engineered to degrade under acidic conditions known to exist in tumor tissue, inflammatory tissue, and diseased cells. The implementation of silyl ether chemistry gave precise control over the rate of degradation and afforded devices that could degrade over the course of hours, days, weeks, or months, depending upon the steric bulk around the silicon atom. These novel materials could be useful for numerous biomedical applications, including drug delivery, tissue repair, and general surgery. © 2010 American Chemical Society.
Details
- Title: Subtitle
- Tunable Bifunctional Silyl Ether Cross-Linkers for the Design of Acid-Sensitive Biomaterials
- Creators
- Matthew C. Parrott - University of North Carolina at Chapel HillJ. Chris Luft - University of North Carolina at Chapel HillJames D. Byrne - University of North Carolina at Chapel HillJohn H. Fain - University of North Carolina at Chapel HillMary E. Napier - University of North Carolina at Chapel HillJoseph M. DeSimone - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- Journal of the American Chemical Society, Vol.132(50), pp.17928-17932
- DOI
- 10.1021/ja108568g
- PMID
- 21105720
- PMCID
- PMC3097112
- NLM abbreviation
- J Am Chem Soc
- ISSN
- 0002-7863
- eISSN
- 1520-5126
- Language
- English
- Date published
- 12/22/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984274858202771
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