Journal article
Tunable Fusion and Aggregation of Liposomes Triggered by Multifunctional Surface-Cross-Linked Micelles
Bioconjugate chemistry, Vol.23(9), pp.1721-1725
09/01/2012
DOI: 10.1021/bc300082b
PMID: 22920227
Abstract
Water-soluble organic nanoparticles were prepared by cross-linking the micelles of a tripropargylated cationic surfactant by a diazide cross-linker in the presence of Cu(I) catalysts. The nanoparticles were decorated with hydrophilic ligands of different lengths on the surface. By interacting with negatively charged liposomes through tunable electrostatic interactions, these nanoparticles induced fusion and leakage of large unilamellar vesicles (LUVs). Fusion or aggregation of the membranes was highly sensitive to the rigidity and phase structures of the membranes, enabling thermally gated fusion to occur within a very narrow window of temperature change.
Details
- Title: Subtitle
- Tunable Fusion and Aggregation of Liposomes Triggered by Multifunctional Surface-Cross-Linked Micelles
- Creators
- Xueshu Li - Iowa State UniversityYan Zhao - Iowa State University
- Resource Type
- Journal article
- Publication Details
- Bioconjugate chemistry, Vol.23(9), pp.1721-1725
- Publisher
- Amer Chemical Soc
- DOI
- 10.1021/bc300082b
- PMID
- 22920227
- ISSN
- 1043-1802
- eISSN
- 1520-4812
- Number of pages
- 5
- Grant note
- DMR-1005515 / NSF; National Science Foundation (NSF) 1005515 / Direct For Mathematical & Physical Scien; National Science Foundation (NSF); NSF - Directorate for Mathematical & Physical Sciences (MPS)
- Language
- English
- Date published
- 09/01/2012
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984303460202771
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