Journal article
Tuning Chromosomal Instability to Optimize Tumor Fitness
Cancer discovery, Vol.7(2), pp.134-136
02/01/2017
DOI: 10.1158/2159-8290.CD-16-1415
PMCID: PMC5312840
PMID: 28167614
Abstract
Low rates of chromosomal instability (CIN) are weakly tumor promoting, whereas high rates of CIN cause cell death and tumor suppression. In this context, Sansregret and colleagues show that one mechanism to restrain excessive CIN in tumor cells and increase fitness is through mutations in the anaphase promoting complex/cyclosome. This serves to delay mitotic progression and decrease the rate of chromosome missegregation. (C) 2017 AACR.
Details
- Title: Subtitle
- Tuning Chromosomal Instability to Optimize Tumor Fitness
- Creators
- Mark E. Burkard - Univ Wisconsin, Dept Med Hematol Oncol, Madison, WI USABeth A. Weaver - University of Wisconsin Carbone Cancer Center
- Resource Type
- Journal article
- Publication Details
- Cancer discovery, Vol.7(2), pp.134-136
- DOI
- 10.1158/2159-8290.CD-16-1415
- PMID
- 28167614
- PMCID
- PMC5312840
- NLM abbreviation
- Cancer Discov
- ISSN
- 2159-8274
- eISSN
- 2159-8290
- Publisher
- Amer Assoc Cancer Research
- Number of pages
- 3
- Grant note
- RSG-15-006-01-CCG / American Cancer Society P30 CA014520 / Carbone Cancer Center Support Grant R01GM097245 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P30CA014520 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01CA140458; R01GM097245 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 02/01/2017
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984700654802771
Metrics
10 Record Views