Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants

Saikat Das; Edward Davis Oldham; Hans-Joachim Lehmler; Barbara L Knutson; Stephen E Rankin

doi:10.1016/j.jcis.2017.10.066

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Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants

Journal article

Peer reviewed

Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants

Saikat Das, Edward Davis Oldham, Hans-Joachim Lehmler, Barbara L Knutson and Stephen E Rankin

Journal of colloid and interface science, Vol.512, pp.428-438

02/15/2018

DOI: 10.1016/j.jcis.2017.10.066

PMID: 29096103

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Abstract

[Display omitted] Emerging applications of carbohydrate/cationic surfactant mixtures require not only synergistic mixing, but also accessible sugar headgroups at the exterior of micelles. A previous study showed that the glucoside headgroups of octyl-β-d-glucopyranoside aggregate at the interior of mixed micelles with equimolar cetyltrimethylammonium bromide rather than mixing with trimethylammonium groups at the corona. The current study tests the hypothesis that structural characteristics of the surfactants (the relative lengths of the alkyl tails and the type of linker) can be tuned to shift the carbohydrate groups to micelle surfaces. The structural arrangement of 30 mM equimolar mixed micelle solutions in D2O is investigated using NMR. The dynamics in different regions are probed using 1H spin-lattice (T1) and spin-spin (T2) relaxation measurements, and relative positioning by nuclear Overhauser effect spectroscopy (NOESY). Additional micellar properties are determined using solvatochromic fluorescent probes. Matching surfactant alkyl tail lengths is found ineffective at “pushing out” the carbohydrate headgroups due to a large mismatch in interactions between the headgroups and D2O. However, inserting a novel polar triazole group between the carbohydrate head group and the hydrophobic tail (e.g. in n-octyl-β-d-xylopyranoside) using click chemistry is able to “pull out” the carbohydrate, thus giving accessible sugar moieties at the surface of mixed micelles.

Self-assembly

Mixing

Sugar surfactants

Supramolecular

Nuclear magnetic resonance

Click chemistry

Micellization

Details

Title: Subtitle: Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants
Creators: Saikat Das - Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506-0046, United States
Edward Davis Oldham - Department of Chemistry, University of Mary Washington, Fredericksburg, VA 22401, United States
Hans-Joachim Lehmler - Department of Environmental and Occupational Health, University of Iowa, Iowa City, IA 52242, United States
Barbara L Knutson - Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506-0046, United States
Stephen E Rankin - Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506-0046, United States
Resource Type: Journal article
Publication Details: Journal of colloid and interface science, Vol.512, pp.428-438
DOI: 10.1016/j.jcis.2017.10.066
PMID: 29096103
NLM abbreviation: J Colloid Interface Sci
ISSN: 0021-9797
eISSN: 1095-7103
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000199, name: U.S. Department of Agriculture, award: 68-3A75-7-608; DOI: 10.13039/100000001, name: National Science Foundation, award: 68-3A75-7-608
Language: English
Date published: 02/15/2018
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute
Record Identifier: 9984001092002771

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