Journal article
Twelve Children with Varicella Vaccine Meningitis: Neuropathogenesis of Reactivated Live Attenuated Varicella Vaccine Virus
Viruses, Vol.12(10), p.1078
09/25/2020
DOI: 10.3390/v12101078
PMCID: PMC7599892
PMID: 32992805
Abstract
Varicella vaccine is a live attenuated varicella-zoster virus (VZV). Like its parental strain called VZV pOka, the vaccine virus vOka retains some neurotropic properties. To better understand vOka neuropathogenesis, we reassessed 12 published cases of vOka meningitis that occurred in once-immunized and twice-immunized children, all of whom had bouts of herpes zoster preceding the central nervous system infection. Eight of the 12 meningitis cases occurred in children who had received only one immunization. There was no pattern to the time interval between varicella vaccination and the onset of herpes zoster with meningitis. Four of the meningitis cases occurred in children who had received two immunizations. Since all four children were 14 years old when meningitis was diagnosed, there was a strong pattern to the interval between the first vaccination at age 1 year and onset of meningitis, namely, 13 years. Knowledge of pathogenesis requires knowledge of the location of herpes zoster; the majority of dermatomal rashes occurred at sites of primary immunization on the arm or thigh, while herpes zoster ophthalmicus was uncommon. Based on this literature review, currently there is no consensus as to the cause of varicella vaccine meningitis in twice-immunized children.
Details
- Title: Subtitle
- Twelve Children with Varicella Vaccine Meningitis: Neuropathogenesis of Reactivated Live Attenuated Varicella Vaccine Virus
- Creators
- Ethan H Heusel - University of IowaCharles Grose - University of Iowa Stead Family Children’s Hospital
- Resource Type
- Journal article
- Publication Details
- Viruses, Vol.12(10), p.1078
- DOI
- 10.3390/v12101078
- PMID
- 32992805
- PMCID
- PMC7599892
- NLM abbreviation
- Viruses
- ISSN
- 1999-4915
- eISSN
- 1999-4915
- Grant note
- AI153817 / NIH HHS R21 AI153817 / NIAID NIH HHS
- Language
- English
- Date published
- 09/25/2020
- Academic Unit
- Stead Family Department of Pediatrics; Pediatric Dentistry; Infectious Disease (Pediatrics)
- Record Identifier
- 9984353943602771
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