Twenty-Four-Hour Blood Pressure Variability Is Associated With Lower Cognitive Performance in Young Women With a Recent History of Preeclampsia

Virginia R Nuckols; Amy K Stroud; Jared F Hueser; Debra S Brandt; Lyndsey E DuBose; Donna A Santillan; Mark K Santillan; Gary L Pierce

doi:10.1093/ajh/hpab112

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Twenty-Four-Hour Blood Pressure Variability Is Associated With Lower Cognitive Performance in Young Women With a Recent History of Preeclampsia

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Twenty-Four-Hour Blood Pressure Variability Is Associated With Lower Cognitive Performance in Young Women With a Recent History of Preeclampsia

Virginia R Nuckols, Amy K Stroud, Jared F Hueser, Debra S Brandt, Lyndsey E DuBose, Donna A Santillan, Mark K Santillan and Gary L Pierce

American journal of hypertension, Vol.34(12), pp.1291-1299

12/01/2021

DOI: 10.1093/ajh/hpab112

PMCID: PMC8643581

PMID: 34278420

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Abstract

Abstract Background Women with a history of preeclampsia (hxPE) exhibit sustained arterial stiffness and elevated blood pressure postpartum. Aortic stiffness and 24-hour blood pressure variability (BPV) are associated with age-related cognitive decline. Although hxPE is related to altered cognitive function, the association between aortic stiffness and BPV with cognitive performance in young women with hxPE has not been investigated. The objectives of this study were to (i) test whether cognitive performance is lower in young women with hxPE and (ii) determine whether aortic stiffness and BPV are associated with cognitive performance independent of 24-hour average blood pressure. Methods Women with hxPE (N = 23) and healthy pregnancy controls (N = 38) were enrolled 1–3 years postpartum. Cognitive performance was assessed in domains of memory, processing speed, and executive function. Twenty-four-hour ambulatory blood pressure monitoring and carotid–femoral pulse wave velocity (cfPWV) were used to measure BPV and aortic stiffness, respectively. Results Women with hxPE had slower processing speed (−0.56 ± 0.17 vs. 0.34 ± 0.11 Z-score, P < 0.001) and lower executive function (−0.43 ± 0.14 vs. 0.31 ± 0.10 Z-score, P = 0.004) compared with controls independent of education, whereas memory did not differ. BPV and cfPWV (adjusted for blood pressure) did not differ between women with hxPE and controls. Greater diastolic BPV was associated with lower executive function independent of 24-hour average blood pressure and education in women with hxPE (r = −0.48, P = 0.03) but not controls (r = 0.15, P = 0.38). Conclusions Select cognitive functions are reduced postpartum in young women with a recent hxPE and linked with elevated 24-hour diastolic BPV. Graphical Abstract Graphical Abstract

Hypertension

ambulatory blood pressure monitoring

blood pressure

pregnancy/preeclampsia

postpartum

pulse wave velocity

Details

Title: Subtitle: Twenty-Four-Hour Blood Pressure Variability Is Associated With Lower Cognitive Performance in Young Women With a Recent History of Preeclampsia
Creators: Virginia R Nuckols - University of Iowa
Amy K Stroud - University of Iowa
Jared F Hueser - University of Iowa
Debra S Brandt - University of Iowa
Lyndsey E DuBose - University of Iowa
Donna A Santillan - University of Iowa
Mark K Santillan - University of Iowa
Gary L Pierce - University of Iowa
Resource Type: Journal article
Publication Details: American journal of hypertension, Vol.34(12), pp.1291-1299
DOI: 10.1093/ajh/hpab112
PMID: 34278420
PMCID: PMC8643581
NLM abbreviation: Am J Hypertens
ISSN: 0895-7061
eISSN: 1879-1905
Publisher: Oxford University Press
Grant note: DOI: 10.13039/100000968, name: American Heart Association, award: 15SFRN23760002, 15SFRN23860007, 18SCG34350001; DOI: 10.13039/100000002, name: National Institutes of Health, award: HL134850, HL084207; DOI: 10.13039/100008893, name: University of Iowa
Language: English
Date published: 12/01/2021
Academic Unit: Obstetrics and Gynecology; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984267255702771

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