Journal article
Twenty Years of Calcium Imaging: Cell Physiology to Dye For
Molecular interventions, Vol.5(2), pp.112-127
04/01/2005
DOI: 10.1124/mi.5.2.8
PMCID: PMC4861218
PMID: 15821159
Abstract
The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca super(2+) in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca super(2+) signaling is accomplished. In excitable cells, the coordination of changing Ca super(2+) concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca super(2+) signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes.
Details
- Title: Subtitle
- Twenty Years of Calcium Imaging: Cell Physiology to Dye For
- Creators
- Harm Knot - University of FloridaIsmail LaherEric SobieSilvia GuatimosimLeticia Gomez-ViquezHali HartmannLong-Sheng SongW LedererWolfgang GraierRoland MalliMaud FriedenOle Petersen
- Resource Type
- Journal article
- Publication Details
- Molecular interventions, Vol.5(2), pp.112-127
- DOI
- 10.1124/mi.5.2.8
- PMID
- 15821159
- PMCID
- PMC4861218
- NLM abbreviation
- Mol Interv
- ISSN
- 1534-0384
- eISSN
- 1543-2548
- Language
- English
- Date published
- 04/01/2005
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9984288715602771
Metrics
6 Record Views