Journal article
Two Clinically Implementable Digital PCR Assessments of DNA Methylation for Diagnosing Heavy Alcohol Consumption
Epigenomes, Vol.9(1), 1
12/24/2024
DOI: 10.3390/epigenomes9010001
PMCID: PMC11755464
PMID: 39846568
Abstract
Background: Heavy alcohol consumption (HAC) has a profound adverse effect on human health. Unfortunately, there is a relative lack of tools that are easily implementable in clinical settings and that can be used to supplement self-reporting in the diagnosis and management of HAC. In part, this paucity is due to limitations of currently available biological measures and a mismatch between available biological measures and the needs of clinicians managing HAC. Objectives: We first review the pros and cons of existing biological measures. Next, we review the underlying theory and the performance characteristics of two recently developed methylation-sensitive digital PCR (MSdPCR) assays, referred to as the Alcohol T Score (ATS) and ZSCAN25, for the assessment of chronic and recent HAC, respectively. Finally, we outline a paradigm for improving the clinical diagnosis and management of alcohol use disorders by utilizing these new markers of alcohol consumption. Conclusions: We conclude that further studies to understand the test performance characteristics of each of these epigenetic tools in larger, diverse populations are in order.
Details
- Title: Subtitle
- Two Clinically Implementable Digital PCR Assessments of DNA Methylation for Diagnosing Heavy Alcohol Consumption
- Creators
- Robert Philibert - University of IowaSteven R. H. Beach - University of GeorgiaAllan M. Andersen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Epigenomes, Vol.9(1), 1
- DOI
- 10.3390/epigenomes9010001
- PMID
- 39846568
- PMCID
- PMC11755464
- NLM abbreviation
- Epigenomes
- ISSN
- 2075-4655
- eISSN
- 2075-4655
- Publisher
- MDPI
- Language
- English
- Date published
- 12/24/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984770892902771
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