Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits

Tim Lebestky; Jung-Sook C Chang; Heiko Dankert; Lihi Zelnik; Young-Cho Kim; Kyung-An Han; Fred W Wolf; Pietro Perona; David J Anderson

doi:10.1016/j.neuron.2009.09.031

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Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits

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Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits

Tim Lebestky, Jung-Sook C Chang, Heiko Dankert, Lihi Zelnik, Young-Cho Kim, Kyung-An Han, Fred W Wolf, Pietro Perona and David J Anderson

Neuron (Cambridge, Mass.), Vol.64(4), pp.522-536

2009

DOI: 10.1016/j.neuron.2009.09.031

PMID: 19945394

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Abstract

Arousal is fundamental to many behaviors, but whether it is unitary or whether there are different types of behavior-specific arousal has not been clear. In Drosophila, dopamine promotes sleep-wake arousal. However, there is conflicting evidence regarding its influence on environmentally stimulated arousal. Here we show that loss-of-function mutations in the D1 dopamine receptor DopR enhance repetitive startle-induced arousal while decreasing sleep-wake arousal (i.e., increasing sleep). These two types of arousal are also inversely influenced by cocaine, whose effects in each case are opposite to, and abrogated by, the DopR mutation. Selective restoration of DopR function in the central complex rescues the enhanced stimulated arousal but not the increased sleep phenotype of DopR mutants. These data provide evidence for at least two different forms of arousal, which are independently regulated by dopamine in opposite directions, via distinct neural circuits.

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Title: Subtitle: Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits
Creators: Tim Lebestky - Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA
Jung-Sook C Chang - Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA
Heiko Dankert - Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA
Lihi Zelnik - Division of Engineering and Applied Science 136-93, California Institute of Technology, Pasadena, CA 91125, USA
Young-Cho Kim - University of Iowa, Neurology
Kyung-An Han - Department of Biology, The Huck Institute, Pennsylvania State University, University Park, PA 16802, USA
Fred W Wolf - Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
Pietro Perona - Division of Engineering and Applied Science 136-93, California Institute of Technology, Pasadena, CA 91125, USA
David J Anderson - Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.64(4), pp.522-536
DOI: 10.1016/j.neuron.2009.09.031
PMID: 19945394
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier Inc
Language: English
Date published: 2009
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984025080902771

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