Journal article
Two Ducts, One Drug-Pembrolizumab-Induced Pancreatic Injury Manifesting as Double-Duct Sign
ACG case reports journal, Vol.12(11), e01878
11/06/2025
DOI: 10.14309/crj.0000000000001878
PMCID: PMC12591698
PMID: 41209351
Abstract
ABSTRACT Immune checkpoint inhibitors (ICIs) can rarely result in ICI-induced pancreatic injury (ICI-PI). Its clinical and radiologic presentation is heterogenous, ranging from asymptomatic radiological signs to severe pancreatitis. Management is mainly with supportive measures and drug discontinuation. In this study, we present an unusual case of ICI-PI, secondary to pembrolizumab, resulting in dilation of both pancreatic and common bile ducts, displaying a "double-duct" sign on imaging. This radiologic sign, commonly associated with malignancy, has not been previously reported with ICI-PI. Endoscopic retrograde cholangiopancreatography with plastic stent placement resulted in quick improvement, highlighting the potential role of endotherapy in treatment of ICI-PI.
Details
- Title: Subtitle
- Two Ducts, One Drug-Pembrolizumab-Induced Pancreatic Injury Manifesting as Double-Duct Sign
- Creators
- Tareq Alsaleh - AdventHealth OrlandoMohamad Khaled Almujarkesh - AdventHealth OrlandoAbdullah Abbasi - AdventHealth OrlandoMustafa Arain - AdventHealth OrlandoJohn George - AdventHealth Orlando
- Resource Type
- Journal article
- Publication Details
- ACG case reports journal, Vol.12(11), e01878
- DOI
- 10.14309/crj.0000000000001878
- PMID
- 41209351
- PMCID
- PMC12591698
- NLM abbreviation
- ACG Case Rep J
- ISSN
- 2326-3253
- eISSN
- 2326-3253
- Publisher
- Wolters Kluwer
- Grant note
- Advent Health Orlando Department of Graduate Medical Education
Financial disclosure: All expenses related to this case report were solely funded by the Advent Health Orlando Department of Graduate Medical Education.
- Language
- English
- Date published
- 11/06/2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985024255302771
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