Journal article
Two Families of TARP Isoforms that Have Distinct Effects on the Kinetic Properties of AMPA Receptors and Synaptic Currents
Neuron (Cambridge, Mass.), Vol.55(6), pp.890-904
2007
DOI: 10.1016/j.neuron.2007.08.024
PMID: 17880893
Abstract
Transmembrane AMPA receptor regulatory proteins (TARPs) are auxiliary AMPA receptor subunits that regulate both the trafficking and gating properties of AMPA receptors, and different TARP isoforms display distinct expression patterns in brain. Here, we compared the effects of four TARP isoforms on the kinetics of AMPA receptor currents. Each isoform slowed the deactivation of GluR1 currents, but the slowing was greatest with γ-4 and γ-8. Isoform-specific differences in desensitization were also observed that correlated with effects on deactivation. TARP isoforms also differentially modulated responses to trains of glutamate applications designed to mimic high-frequency presynaptic firing. Importantly, whereas both stargazin and γ-4 rescued excitatory synaptic transmission in cerebellar granule cells from
stargazer mice, the decay of miniature EPSCs was 2-fold slower in neurons expressing γ-4. The results show that heterogeneity in the composition of AMPA receptor/TARP complexes contributes to synapse-specific differences in EPSC decays and frequency-dependent modulation of neurotransmission.
Details
- Title: Subtitle
- Two Families of TARP Isoforms that Have Distinct Effects on the Kinetic Properties of AMPA Receptors and Synaptic Currents
- Creators
- Chang-Hoon Cho - Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066, USAFannie St-Gelais - Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066, USAWei Zhang - Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066, USASusumu Tomita - Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066, USAJames R Howe - Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066, USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.55(6), pp.890-904
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuron.2007.08.024
- PMID
- 17880893
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100001207, name: Esther A. and Joseph Klingenstein Fund
- Language
- English
- Date published
- 2007
- Academic Unit
- Surgery
- Record Identifier
- 9984051791902771
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