Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly

Shilpa Gurnurkar; Unnati Patel; Jennifer Seekford; Mauri Carakushansky; Madhuradhar Chegondi

doi:10.7759/cureus.31604

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Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly

Journal article

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Peer reviewed

Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly

Shilpa Gurnurkar, Unnati Patel, Jennifer Seekford, Mauri Carakushansky and Madhuradhar Chegondi

Curēus (Palo Alto, CA), Vol.14(11), p.e31604

11/17/2022

DOI: 10.7759/cureus.31604

PMCID: PMC9757648

PMID: 36540490

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Abstract

Gigantism and acromegaly are most commonly caused by a growth hormone (GH)-secreting pituitary adenoma. Pediatric cases are diagnostically and therapeutically challenging due to their insidious nature. This article presents two adolescent females who were referred to the endocrinology clinic primarily for the evaluation of menstrual disorders rather than for concerns about GH excess. Patient one was a 16-year-old who presented with primary amenorrhea and tall stature, and patient two, a 15-year-old, presented with a history of irregular menstruation. Both patients were noted to have acromegalic features, and an extensive work-up confirmed GH-secreting pituitary adenomas. In addition, patient two had significant hyperprolactinemia. Transsphenoidal tumor resection was performed on both patients; patient one had a successful complete resection and achieved endocrine remission, while patient two underwent partial resection followed by a short clinical trial of pegvisomant without significant success. Improved clinical knowledge through case reports can assist with the early diagnosis and management of such rare pediatric conditions.

acromegaly

Diabetes

Endocrinology

gigantism

growth hormone

Metabolism

pediatric

pituitary adenoma

Details

Title: Subtitle: Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly
Creators: Shilpa Gurnurkar - Pediatric Endocrinology, Nemours Children's Hospital, Florida, Orlando, USA Pediatrics/Critical Care Medicine, Carver College of Medicine, University of Iowa, Iowa City, USA
Unnati Patel - Pediatric Endocrinology, Nemours Children's Hospital, Florida, Orlando, USA Pediatrics/Critical Care Medicine, Carver College of Medicine, University of Iowa, Iowa City, USA
Jennifer Seekford - Pediatric Endocrinology, Nemours Children's Hospital, Florida, Orlando, USA Pediatrics/Critical Care Medicine, Carver College of Medicine, University of Iowa, Iowa City, USA
Mauri Carakushansky - Pediatric Endocrinology, Nemours Children's Hospital, Florida, Orlando, USA Pediatrics/Critical Care Medicine, Carver College of Medicine, University of Iowa, Iowa City, USA
Madhuradhar Chegondi - University of Iowa
Resource Type: Journal article
Publication Details: Curēus (Palo Alto, CA), Vol.14(11), p.e31604
DOI: 10.7759/cureus.31604
PMID: 36540490
PMCID: PMC9757648
NLM abbreviation: Cureus
ISSN: 2168-8184
eISSN: 2168-8184
Publisher: Cureus
Language: English
Date published: 11/17/2022
Academic Unit: Stead Family Department of Pediatrics
Record Identifier: 9984354404902771

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