Two cases of aggressive sarcomatoid urothelial carcinoma reveal potential molecular targets

Alexandria Hertz; L Lerma; Justin Ahn; Judith Hagedorn; Eric Konnick; Robin Bennett; Petros Grivas; Michael Wagner; Nicholas Reder; Sarah Psutka

doi:10.24911/ejmcr/173-1611205898

Journal article

Two cases of aggressive sarcomatoid urothelial carcinoma reveal potential molecular targets

Alexandria Hertz, L Lerma, Justin Ahn, Judith Hagedorn, Eric Konnick, Robin Bennett, Petros Grivas, Michael Wagner, Nicholas Reder and Sarah Psutka

European Journal of Medical Case Reports, Vol.5(8), pp.1-8

01/01/2021

DOI: 10.24911/ejmcr/173-1611205898

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Abstract

Background: To detail two cases of sarcomatoid urothelial carcinoma (UC) with rapid progression, disseminated metastases, and early death, detailing the results of somatic tumor profiling using next-generation sequencing (NGS). Case Series: The first case presented is a rare case of UC of the renal pelvis with osteosarcomatous differentiation and venous tumor thrombus in a 65-year-old man found to have a heterozygous germline variant of unknown significance in the neurofibromatosis-1 gene. The second case is a 72-year-old woman with sarcomatoid UC of the bladder. Herein, we discuss the presentation and clinical course, histology, immunohistochemical profiles, and somatic tumor testing results. We then review the literature regarding this rare and aggressive entity, detail options for optimal management, and address the role of molecular profiling in these cases. Conclusion: Sarcomatoid UC is a rare and aggressive entity. NGS may be useful in these cases to guide systemic therapy.

Biopsy

Bladder

Bladder cancer

Blood clots

Bone cancer

Case reports

Cellular biology

Genetic counseling

Hematuria

Histology

Kidney cancer

Metastasis

Mutation

Sarcoma

Surveillance

Tumors

Urology

Veins & arteries

Details

Title: Subtitle: Two cases of aggressive sarcomatoid urothelial carcinoma reveal potential molecular targets
Creators: Alexandria Hertz
L Lerma
Justin Ahn
Judith Hagedorn
Eric Konnick
Robin Bennett
Petros Grivas
Michael Wagner
Nicholas Reder
Sarah Psutka
Resource Type: Journal article
Publication Details: European Journal of Medical Case Reports, Vol.5(8), pp.1-8
DOI: 10.24911/ejmcr/173-1611205898
ISSN: 2520-4998
eISSN: 2520-4998
Publisher: Discover Publishing Group
Number of pages: 8
Language: English
Date published: 01/01/2021
Academic Unit: Urology
Record Identifier: 9984920837402771

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