Journal article
Two cases of brand-specific albumin sensitivity in patients receiving regular therapeutic plasma exchange
Transfusion and apheresis science, Vol.60(2), pp.103047-103047
04/2021
DOI: 10.1016/j.transci.2020.103047
PMID: 33422406
Abstract
Therapeutic plasma exchange (PLEX) involves the removal of detrimental substances, commonly pathogenic antibodies or toxins, from a patient's blood by exchanging their plasma with a replacement fluid. While a variety of replacement fluids are available, human albumin (4-5 %) is the most commonly used, as it is widely available, easily stored, and generally well tolerated. Despite its excellent safety profile, adverse reactions to albumin are well documented, ranging in severity from mild allergic symptoms to severe anaphylaxis. This report describes two cases of patients receiving frequent PLEX who developed sensitivities to human albumin. These patients differed substantially in the manifestations of their symptoms, the duration of their treatment, and their medical indication for PLEX. In both cases, symptom onset occurred shortly after completion of plasma exchange procedures and lasted for several hours. Symptoms disappeared when the patients were switched to albumin from a different manufacturer, suggesting that the reaction was specific to that formulation of albumin and not to the albumin itself. These cases highlight the possibility of manufacturer-specific acquired albumin sensitivities and provide a simple framework for the initial approach to the management of such reactions.
Details
- Title: Subtitle
- Two cases of brand-specific albumin sensitivity in patients receiving regular therapeutic plasma exchange
- Creators
- Kai J Rogers - University of IowaAnnette J Schlueter - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Transfusion and apheresis science, Vol.60(2), pp.103047-103047
- DOI
- 10.1016/j.transci.2020.103047
- PMID
- 33422406
- ISSN
- 1473-0502
- eISSN
- 1878-1683
- Language
- English
- Date published
- 04/2021
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984186634302771
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