Journal article
Two isomeric dideoxynucleosides
Acta crystallographica. Section C, Crystal structure communications, Vol.56(8), pp.e343-e345
08/2000
DOI: 10.1107/S0108270100008921
Abstract
We have synthesized two isomeric dideoxynucleosides. 4(S)-(6-Amino-9H-purin-9-yl)-3-methylene-2,3,4,5-tetrahydrofuran-2(S)-ylmethanol, C11H13N5O2, is an analogue of the anti-HIV compound (S,S)-isodideoxyadenosine (isoDDA) with an exocyclic methylene group and is found to be anti-HIV inactive. The solid-state comformation is very similar to that of isoDDA. 4(S)-(6-Amino-3H-purin-3-yl)-3-methylene-2,3,4,5-tetrahydrofuran-2(S)-ylmethanol, C11H13N5O2, has an isomeric arrangement of the carbohydrate and base moieties, as confirmed by the crystal structure analysis. The asymmetric unit contains two independent molecules that differ in conformations at the sugar moiety.
Details
- Title: Subtitle
- Two isomeric dideoxynucleosides
- Creators
- Dale C. Swenson - University of IowaVasu Nair - University of IowaSanjib Bera - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Acta crystallographica. Section C, Crystal structure communications, Vol.56(8), pp.e343-e345
- Publisher
- Munksgaard International Publishers
- DOI
- 10.1107/S0108270100008921
- ISSN
- 0108-2701
- eISSN
- 1600-5759
- Language
- English
- Date published
- 08/2000
- Academic Unit
- Chemistry
- Record Identifier
- 9984635115502771
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