Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial

Andrew H Cragg; Tony P Smith; John D Corson; Nobuo Nakagawa; F Castaneda; T F Kresowik; W J Sharp; A Shamma; K S Berbaum

doi:10.1148/radiology.178.3.1994402

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Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial

Journal article

Peer reviewed

Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial

Andrew H Cragg, Tony P Smith, John D Corson, Nobuo Nakagawa, F Castaneda, T F Kresowik, W J Sharp, A Shamma and K S Berbaum

Radiology, Vol.178(3), pp.681-686

03/1991

DOI: 10.1148/radiology.178.3.1994402

PMID: 1994402

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Abstract

The effects of two urokinase (UK) dose regimens on lysis time, lytic success, primary clinical success, and frequency of complications of peripheral thrombolysis were compared. Seventy-two intraarterial UK infusions were performed by means of standard catheter-directed infusion techniques in 63 patients with symptomatic peripheral arterial or bypass graft occlusions. Patients were prospectively randomized to high-dose (250,000 U/h for 4 hours and then 125,000 U/h) or low-dose (50,000 U/h) regimens. The mean time to complete lysis was 20.8, 26.0, 16.5, and 18.2 hours for the high-dose artery, low-dose artery, high-dose graft, and low-dose graft groups, respectively (P was not significant). Respective mean infusion durations were 27.1, 35.4, 22.2, and 25.3 hours. Clinical success was achieved in 65%-85% of cases. The frequency of complications was equivalent between groups, except for a higher frequency of minor bleeding complications in the high-dose group. The two urokinase dose regimens studied were equally effective in enabling peripheral thrombolysis.

Angiography

Urokinase-Type Plasminogen Activator - therapeutic use

Prospective Studies

Graft Occlusion, Vascular - diagnostic imaging

Humans

Middle Aged

Male

Thrombosis - diagnostic imaging

Extremities - blood supply

Time Factors

Graft Occlusion, Vascular - drug therapy

Thrombolytic Therapy

Female

Thrombosis - drug therapy

Urokinase-Type Plasminogen Activator - administration & dosage

Infusions, Intra-Arterial

Details

Title: Subtitle: Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial
Creators: Andrew H Cragg - Department of Radiology, University of Iowa College of Medicine, Iowa City
Tony P Smith
John D Corson
Nobuo Nakagawa
F Castaneda
T F Kresowik
W J Sharp
A Shamma
K S Berbaum
Resource Type: Journal article
Publication Details: Radiology, Vol.178(3), pp.681-686
Publisher: United States
DOI: 10.1148/radiology.178.3.1994402
PMID: 1994402
ISSN: 0033-8419
eISSN: 1527-1315
Language: English
Date published: 03/1991
Academic Unit: Radiology; Surgery
Record Identifier: 9984051597802771

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