Journal article
Tying Small Changes to Large Outcomes: The Cautious Promise in Incorporating the Microbiome into Immunotherapy
International journal of molecular sciences, Vol.22(15), p.7900
08/01/2021
DOI: 10.3390/ijms22157900
PMCID: PMC8347117
PMID: 34360663
Abstract
The role of the microbiome in immunology is a rapidly burgeoning topic of study. Given the increasing use of immune checkpoint inhibitor (ICI) therapy in cancers, along with the recognition that carcinogenesis has been linked to dysregulations of the immune system, much attention is now directed at potentiation of ICI efficacy, as well as minimizing the incidence of treatment-associated immune-related adverse events (irAEs). We provide an overview of the major research establishing links between the microbiome to tumorigenesis, chemotherapy and radiation potentiation, and ICI efficacy and irAE development.
Details
- Title: Subtitle
- Tying Small Changes to Large Outcomes: The Cautious Promise in Incorporating the Microbiome into Immunotherapy
- Creators
- Justin Chau - University of Iowa Hospitals and ClinicsJun Zhang - University of Kansas Medical Center
- Resource Type
- Journal article
- Publication Details
- International journal of molecular sciences, Vol.22(15), p.7900
- DOI
- 10.3390/ijms22157900
- PMID
- 34360663
- PMCID
- PMC8347117
- NLM abbreviation
- Int J Mol Sci
- ISSN
- 1661-6596
- eISSN
- 1422-0067
- Publisher
- Mdpi
- Number of pages
- 14
- Grant note
- "Play with a Pro" Lung Cancer Research Fund University of Kansas Medical Center Start-up Funds University of Kansas Cancer Center
- Language
- English
- Date published
- 08/01/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359697302771
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