USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections?

Kristen M Kreisel; O. Colin Stine; J. Kristie Johnson; Eli N Perencevich; Michelle D Shardell; Alan J Lesse; Fred M Gordin; Michael W Climo; Mary-Claire Roghmann

doi:10.1016/j.diagmicrobio.2011.03.010

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USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections?

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USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections?

Kristen M Kreisel, O. Colin Stine, J. Kristie Johnson, Eli N Perencevich, Michelle D Shardell, Alan J Lesse, Fred M Gordin, Michael W Climo and Mary-Claire Roghmann

Diagnostic Microbiology & Infectious Disease, Vol.70(3), pp.285-290

07/2011

DOI: 10.1016/j.diagmicrobio.2011.03.010

PMID: 21558047

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https://www.ncbi.nlm.nih.gov/pmc/articles/3118841View

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Abstract

USA300 methicillin-resistant Staphylococcus aureus (MRSA) is increasing as a cause of severe community-associated bacteremic infections. We assessed severe sepsis in response to infection in patients with USA300 MRSA compared to non-USA300 MRSA bacteremia. A cohort study was conducted from 1997 to 2008 comparing sepsis in response to infection in 271 patients with MRSA bacteremia from 4 VA hospitals. Sixty-seven (25%) patients with MRSA bacteremia were USA300 MRSA; 204 (75%) were non-USA300 MRSA. The proportion of MRSA bacteremia caused by USA300 MRSA increased over time (χ2P < 0.0001). Adjusting for age and nosocomial infection, patients with USA300 MRSA bacteremia were more likely to have severe sepsis or septic shock in response to infection than patients with non-USA300 MRSA bacteremia (adjusted relative risk = 1.82; 95% confidence interval, 1.16–2.87; P = 0.01). This suggests that patients with USA300 MRSA are more likely to develop severe sepsis in response to their infection, which could be due to host or bacterial differences.

Community-acquired infections

Electrophoresis

Pulsed-field

Methicillin resistance

Bacterial typing techniques

Staphylococcus aureus

Bacteremia

Gel

Details

Title: Subtitle: USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections?
Creators: Kristen M Kreisel - University of Maryland Baltimore, Baltimore, MD 21201, USA
O. Colin Stine - University of Maryland Baltimore, Baltimore, MD 21201, USA
J. Kristie Johnson - University of Maryland Baltimore, Baltimore, MD 21201, USA
Eli N Perencevich - University of Maryland Baltimore, Baltimore, MD 21201, USA
Michelle D Shardell - University of Maryland Baltimore, Baltimore, MD 21201, USA
Alan J Lesse - VA Western New York Healthcare System, Buffalo, NY 14215, USA
Fred M Gordin - Washington DC VA Medical Center, Washington, DC 20422, USA
Michael W Climo - Hunter Holmes McGuire VA Medical Center, Richmond, VA 23249, USA
Mary-Claire Roghmann - University of Maryland Baltimore, Baltimore, MD 21201, USA
Resource Type: Journal article
Publication Details: Diagnostic Microbiology & Infectious Disease, Vol.70(3), pp.285-290
DOI: 10.1016/j.diagmicrobio.2011.03.010
PMID: 21558047
NLM abbreviation: Diagn Microbiol Infect Dis
ISSN: 0732-8893
eISSN: 1879-0070
Publisher: Elsevier Inc
Grant note: name: Centers for Disease Control and Prevention to K.M.K, award: R36, M01, RR016500, K12 RR023250-03; name: University of Maryland General Clinical Research Center; name: General Clinical Research Centers Program, National Center for Research Resources (NCRR), NIH; name: National Institutes of Health to J.K.J.
Language: English
Date published: 07/2011
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983779289102771

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