Journal article
Ubiquitin-Dependent Sorting in Endocytosis
Cold Spring Harbor perspectives in biology, Vol.6(1), pp.a016808-a016808
01/01/2014
DOI: 10.1101/cshperspect.a016808
PMCID: PMC3941215
PMID: 24384571
Abstract
When ubiquitin (Ub) is attached to membrane proteins on the plasma membrane, it directs them through a series of sorting steps that culminate in their delivery to the lumen of the lysosome where they undergo complete proteolysis. Ubiquitin is recognized by a series of complexes that operate at a number of vesicle transport steps. Ubiquitin serves as a sorting signal for internalization at the plasma membrane and is the major signal for incorporation into intraluminal vesicles of multivesicular late endosomes. The sorting machineries that catalyze these steps can bind Ub via a variety of Ub-binding domains. At the same time, many of these complexes are themselves ubiquitinated, thus providing a plethora of potential mechanisms to regulate their activity. Here we provide an overview of how membrane proteins are selected for ubiquitination and deubiquitination within the endocytic pathway and how that ubiquitin signal is interpreted by endocytic sorting machineries.
Details
- Title: Subtitle
- Ubiquitin-Dependent Sorting in Endocytosis
- Creators
- Robert C. Piper - University of IowaIvan Dikic - 2Buchmann Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, D-60590 Frankfurt, GermanyGergely L. Lukacs - McGill University
- Resource Type
- Journal article
- Publication Details
- Cold Spring Harbor perspectives in biology, Vol.6(1), pp.a016808-a016808
- DOI
- 10.1101/cshperspect.a016808
- PMID
- 24384571
- PMCID
- PMC3941215
- NLM abbreviation
- Cold Spring Harb Perspect Biol
- ISSN
- 1943-0264
- eISSN
- 1943-0264
- Publisher
- Cold Spring Harbor Lab Press, Publications Dept
- Number of pages
- 21
- Grant note
- R01GM058202 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01 GM058202 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 01/01/2014
- Academic Unit
- Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
- Record Identifier
- 9984297597502771
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