Journal article
Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules
Developmental cell, Vol.36(1), pp.63-78
01/11/2016
DOI: 10.1016/j.devcel.2015.12.017
PMID: 26766443
Abstract
Mitosis ensures equal segregation of the genome and is controlled by a variety of ubiquitylation signals on substrate proteins. However, it remains unexplored how the versatile ubiquitin code is read out during mitotic progression. Here, we identify the ubiquitin receptor protein UBASH3B as an important regulator of mitosis. UBASH3B interacts with ubiquitylated Aurora B, one of the main kinases regulating chromosome segregation, and controls its subcellular localization but not protein levels. UBASH3B is a limiting factor in this pathway and is sufficient to localize Aurora B to microtubules prior to anaphase. Importantly, targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells. Our findings uncover an important mechanism defining how ubiquitin attachment to a substrate protein is decoded during mitosis.
Details
- Title: Subtitle
- Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules
- Creators
- Ksenia Krupina - Université de StrasbourgCharlotte Kleiss - Institut de génétique et de biologie moléculaire et cellulaireThibaud Metzger - Institut de génétique et de biologie moléculaire et cellulaireSadek Fournane - Institut de génétique et de biologie moléculaire et cellulaireStephane Schmucker - Université de StrasbourgKay Hofmann - University of CologneBenoit Fischer - InsermNicodeme Paul - Université de StrasbourgIain Malcolm Porter - University of DundeeWolfgang Raffelsberger - InsermOlivier Poch - Université de StrasbourgJason Reese Swedlow - University of DundeeLaurent Brino - InsermIzabela Sumara - Inserm
- Resource Type
- Journal article
- Publication Details
- Developmental cell, Vol.36(1), pp.63-78
- DOI
- 10.1016/j.devcel.2015.12.017
- PMID
- 26766443
- NLM abbreviation
- Dev Cell
- ISSN
- 1534-5807
- eISSN
- 1878-1551
- Publisher
- Elsevier
- Number of pages
- 16
- Grant note
- Region Alsace; Region Grand-Est Fondation ARC pour la recherche sur le cancer; Fondation ARC pour la Recherche sur le Cancer IGBMC Sanofi-Aventis ANR-10-IDEX-0002-02 / Agence Nationale de la Recherche; Agence Nationale de la Recherche (ANR) INSERM; Institut National de la Sante et de la Recherche Medicale (Inserm) R10076MS / ATIP-AVENIR La Ligue Contre le Cancer; Ligue nationale contre le cancer Conectus Alsace; Region Grand-Est 095931/Z/11/Z; 097945/B/11/Z / Wellcome Trust
- Language
- English
- Date published
- 01/11/2016
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9985134036802771
Metrics
1 Record Views