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Ubiquitin ligases in T cell activation and autoimmunity
Journal article   Peer reviewed

Ubiquitin ligases in T cell activation and autoimmunity

Jian Zhang
Clinical Immunology, Vol.111(3), pp.234-240
06/2004
DOI: 10.1016/j.clim.2004.02.003
PMID: 15183144

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Abstract

Ubiquitination-mediated protein modifications are increasingly recognized as key regulatory events in many basic cell biology processes. A key class of enzymes called ubiquitin ligases, which has been shown to play a crucial role in the ubiquitination process, can positively or negatively regulate T cell responses. This review summarizes the recent advances defining the roles of several ubiquitin ligases in T cell activation and autoimmunity.
Autoimmunity T cell Ubiquitination

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