Journal article
Ubiquitination and the Ubiquitin–Proteasome System as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer
Tumor biology, Vol.33(4), pp.897-910
08/01/2012
DOI: 10.1007/s13277-012-0355-x
PMID: 22399444
Abstract
Epithelial to Mesenchymal Transition (EMT) in cancer is a process that allows cancer cells to detach from neighboring cells, become mobile and metastasize and shares many signaling pathways with development. Several molecular mechanisms which regulate oncogenic properties in neoplastic cells such as proliferation, resistance to apoptosis and angiogenesis through transcription factors or other mediators are also regulators of EMT. These pathways and downstream transcription factors are, in their turn, regulated by ubiquitination and the Ubiquitin–Proteasome System (UPS). Ubiquitination, the covalent link of the small 76-amino acid protein ubiquitin to target proteins, serves as a signal for protein degradation by the proteasome or for other outcomes such as endocytosis, degradation by the lysosome or directing these proteins to specific cellular compartments. This review discusses aspects of the regulation of EMT by ubiquitination and the UPS and underlines its complexity focusing on transcription and transcription factors regulating EMT and are being regulated by ubiquitination.
Details
- Title: Subtitle
- Ubiquitination and the Ubiquitin–Proteasome System as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer
- Creators
- Ioannis A. Voutsadakis - Centre Pluridisciplinaire d’Oncologie, BH06, Centre Hospitalier Universitaire Vaudois
- Resource Type
- Journal article
- Publication Details
- Tumor biology, Vol.33(4), pp.897-910
- DOI
- 10.1007/s13277-012-0355-x
- PMID
- 22399444
- NLM abbreviation
- Tumour Biol
- ISSN
- 1010-4283
- eISSN
- 1423-0380
- Publisher
- Springer Netherlands
- Number of pages
- 14
- Language
- English
- Date published
- 08/01/2012
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806614902771
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