Journal article
Ubiquitous Molecular Substrates for Associative Learning and Activity-Dependent Neuronal Facilitation
Reviews in the neurosciences, Vol.9(3), pp.129-168
01/1998
DOI: 10.1515/REVNEURO.1998.9.3.129
PMID: 9833649
Abstract
Recent evidence suggests that many of the molecular cascades and substrates that contribute to learning-related forms of neuronal plasticity may be conserved across ostensibly disparate model systems. Notably, the facilitation of neuronal excitability and synaptic transmission that contribute to associative learning in Aplysia and Hermissenda, as well as associative LTP in hippocampal CA1 cells, all require (or are enhanced by) the convergence of a transient elevation in intracellular Ca2+ with transmitter binding to metabotropic cell-surface receptors. This temporal convergence of Ca2+ and G-protein-stimulated second-messenger cascades synergistically stimulates several classes of serine/threonine protein kinases, which in turn modulate receptor function or cell excitability through the phosphorylation of ion channels. We present a summary of the biophysical and molecular constituents of neuronal and synaptic facilitation in each of these three model systems. Although specific components of the underlying molecular cascades differ across these three systems, fundamental aspects of these cascades are widely conserved, leading to the conclusion that the conceptual semblance of these superficially disparate systems is far greater than is generally acknowledged. We suggest that the elucidation of mechanistic similarities between different systems will ultimately fulfill the goal of the model systems approach, that is, the description of critical and ubiquitous features of neuronal and synaptic events that contribute to memory induction.
Details
- Title: Subtitle
- Ubiquitous Molecular Substrates for Associative Learning and Activity-Dependent Neuronal Facilitation
- Creators
- Louis D. Matzel - Rutgers, The State University of New JerseyAndrew C. Talk - Rutgers, The State University of New JerseyIsabel A. Muzzio - BiologyRonald F. Rogers - Indiana University Bloomington
- Resource Type
- Journal article
- Publication Details
- Reviews in the neurosciences, Vol.9(3), pp.129-168
- DOI
- 10.1515/REVNEURO.1998.9.3.129
- PMID
- 9833649
- NLM abbreviation
- Rev Neurosci
- ISSN
- 0334-1763
- eISSN
- 2191-0200
- Language
- English
- Date published
- 01/1998
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984295027902771
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