Logo image
Back
Ubiquitous nature of distal athero/thromboembolic events during lower extremity atherectomy procedures involving the superficial femoral artery
Journal article   Peer reviewed

Ubiquitous nature of distal athero/thromboembolic events during lower extremity atherectomy procedures involving the superficial femoral artery

Najam Wasty, M. Z. Khakwani, Spas Kotev, Catalin Boiangiu, Omar Hasan, Manjusha Anna, Rajiv Tayal, Khalil Kaid, Gail Baker and Marc Cohen
The International journal of angiology, Vol.25(4), pp.252-257
12/01/2016
DOI: 10.1055/s-0036-1587694
PMCID: PMC5114138
PMID: 27867291

View Online

Abstract

This study aims to evaluate occurrence, size, composition, and clinical significance of embolized debris during superficial femoral artery atherectomy using all commercially available atherectomy devices. Distal athero/thromboembolic events (DATE) are a universal phenomenon in lower extremity atherectomy procedures (LEAPs) due to the sheer volume of atheroma and the thrombus burden in peripheral arterial disease. Some of these events can be clinically significant. We prospectively gathered clinical and histopathological data on all commercially available atherectomy devices by using embolic protection devices (EPD) in every case. After intervention, the contents of EPD were examined both microscopically and macroscopically. Data from 59 consecutive patients undergoing LEAP were analyzed. DATE occurred 100% of the time. The composition of particulate debris varied with the device used. Grossly visible agglomerated debris was captured by the filter in the majority of patients 54/59 (91.5%). Clinically significant debris, defined by the Preventing Lower Extremity Distal Embolization Using Embolic Filter Protection registry as particle diameter > 0.2 cm, was found in 33/59 (56%) patients. The size of captured debris particles ranged from 0.1 to 2.4 mm. While DATE occurred in all patients, clinically significant DATE occurred in 56% patients undergoing LEAP regardless of the atherectomy device. In spite of a large fraction of the clinically significant debris occurring on our routine dual antiplatelet regimen, no patient suffered an amputation. Although DATE was prevented by the use of EPD in all 59 cases, more data are needed to determine whether the use of EPD translates into a long-term clinical benefit. Use of EPD and optimal thromboprophylaxis should be considered in patients, especially in the setting of compromised distal runoff.
 atherectomy cardiac catheterization endovascular procedures peripheral arterial thromboembolism

Details

Metrics

7 Record Views
Logo image