Journal article
Ultrasound measurement of knee synovial fluid during external pneumatic compression
Journal of orthopaedic research, Vol.37(3), pp.601-608
03/01/2019
DOI: 10.1002/jor.24216
PMID: 30644131
Abstract
Synovial fluid based biomarker research has been limited by the small volumes of synovial fluid from the knees of some patients. We used ultrasound (US) to determine if synovial fluid could be displaced into an access port during pneumatic compression to 100mmHg. Forty knees from 37 consecutive arthritis patients with rheumatoid arthritis -25, osteoarthritis -8, psoriatic arthritis -2, and 1 each with systemic lupus erythematosus and gout were evaluated. This group of 28 females and 9 males with a median age of 59 years and an average body mass index of 26.9kg/m(2) had previously undergone a diagnostic arthrocentesis and or a therapeutic knee injection using this pneumatic compression device. Blinded digital image analysis of the anechoic region on ultrasound demonstrated an increase in fluid within the 9cmx6cm access port (anterolateral or anteromedial joint) during inflation in all patients with a 2.5-3.5 fold increase in fluid area and a 2-3 fold increase in fluid depth after inflation, p<0.001. Statement of clinical significance: External pneumatic compression to the knee provides a larger volume of synovial fluid under positive pressure which should allow investigators to achieve greater success in obtaining synovial fluid during arthrocentesis for biomarker research or provide more precise therapeutic injections than traditional non image-guided anatomical landmark-based techniques. (c) 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Details
- Title: Subtitle
- Ultrasound measurement of knee synovial fluid during external pneumatic compression
- Creators
- Richard Meehan - Department of Medicine RheumatologyDivision National Jewish HealthDenverColoradoChris Wilson - University of Colorado Anschutz Medical CampusEric Hoffman - National Jewish HealthLynne Altimier - Department of RadiologyNational Jewish HealthDenverColoradoMaryanne Kaessner - Department of Nursing National Jewish HealthDenverColoradoElizabeth A. Regan - National Jewish Health
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic research, Vol.37(3), pp.601-608
- DOI
- 10.1002/jor.24216
- PMID
- 30644131
- NLM abbreviation
- J Orthop Res
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- State of Colorado Office of Economic Development and International Trade, Advanced Industries Accelerator Grant Program
- Language
- English
- Date published
- 03/01/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318781502771
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