Journal article
Ultrasound-triggered PLGA microparticle destruction and degradation for controlled delivery of local cytotoxicity and drug release
International journal of biological macromolecules, Vol.106, pp.1211-1217
01/2018
DOI: 10.1016/j.ijbiomac.2017.08.125
PMID: 28851638
Abstract
[Display omitted]
•The patterns of sustained DOX release from MPs were observed approximately 6h following the initial period of burst release.•A certain portion of US-resistant MPs undergo accelerated degradation by repetitive sonication.•DC-modulated sonication can be used to control the cytotoxicity and release of DOX via MPs destruction and degradation.
In this study, we investigated the low intensity ultrasound (US)-controlled delivery of local cytotoxicity and drug release via induced destruction and degradation of microparticles (MPs) made of poly(lactic-co-glycolic acid) (PLGA). This study was conducted in vitro with potential application towards tumor treatment in conjunction with direct injection. MPs, either loaded with or without doxorubicin (DOX), were prepared using a double-emulsion solvent-evaporation technique. First, the MPs were exposed to US with duty cycle (DC)-modulation. The destruction and degradation of MPs were evaluated using light and scanning electron microscopy. Second, the effects of US-mediated destruction/degradation of MPs on the local cytotoxicity as well as DOX release were evaluated. US-triggered MP destruction/degradation significantly enhanced nearby cell death and DOX release. These affects occurred in proportion to the DC. Our findings indicate that controlled cytotoxicity and DOX release by US could be useful in developing the minimally invasive therapeutic applications for tumor treatment.
Details
- Title: Subtitle
- Ultrasound-triggered PLGA microparticle destruction and degradation for controlled delivery of local cytotoxicity and drug release
- Creators
- Kee W Jang - Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr., Bethesda, MD 20892, United StatesDongrim Seol - Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA, United StatesLei Ding - Jiangnan University Wuxi Medical School, Wuxi, Jiangsu, ChinaDong Nyoung Heo - Department of Dental Materials, School of Dentistry, Kyung Hee University, Seoul, Republic of KoreaSang Jin Lee - Department of Dental Materials, School of Dentistry, Kyung Hee University, Seoul, Republic of KoreaJames A Martin - Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA, United StatesIl Keun Kwon - Department of Dental Materials, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea
- Resource Type
- Journal article
- Publication Details
- International journal of biological macromolecules, Vol.106, pp.1211-1217
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ijbiomac.2017.08.125
- PMID
- 28851638
- ISSN
- 0141-8130
- eISSN
- 1879-0003
- Grant note
- name: Bio & Medical Technology Development Program of the National Research Foundation (NRF); name: Korean government, award: 2017M3A9E4048170
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthodontics; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation
- Record Identifier
- 9984040236702771
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