Journal article
Ultraviolet Radiation Exposure is Associated with Clinical and Autoantibody Phenotypes in Juvenile Myositis
Arthritis and rheumatism, Vol.65(7), pp.1934-1941
07/2013
DOI: 10.1002/art.37985
PMCID: PMC3727975
PMID: 23658122
Abstract
Objective
Genetic and environmental factors may contribute to the etiology of the juvenile idiopathic inflammatory myopathies (IIMs), which are systemic autoimmune diseases that are characterized by muscle and skin inflammation. We undertook this study to investigate the association between ultraviolet radiation (UVR) exposure and the clinical and autoantibody expression of juvenile IIM.
Methods
The relationship between UVR exposure in the month before symptom onset and the prevalence of juvenile dermatomyositis (DM), compared to juvenile polymyositis (PM), was assessed in 298 juvenile IIM patients. Among the patients with juvenile DM, the association between UVR exposure and presence of myositis autoantibodies was assessed. Regression models were stratified by sex and race. The association between the regional UV index in US geoclimatic zones and the clinical and autoantibody subgroups was examined by weighted least squares regression analysis.
Results
Among girls in this population, the odds of having juvenile DM, compared to juvenile PM, increased per unit increase in the patients' highest UV index in the month before symptom onset (odds ratio [OR] 1.18, 95% confidence interval 1.00–1.40). Moreover, both the mean and highest UV indices were associated with increasing odds of having anti-p155/140 autoantibodies, with the strongest odds in white males (ORs of 1.30 and 1.23, respectively). No association was observed between the UV index and presence of anti-MJ autoantibodies or lack of any myositis autoantibodies. Across all 9 US geoclimatic regions, the mean UV index was associated with increasing odds of having juvenile DM and anti-p155/140 autoantibodies, but decreasing odds of having anti-MJ autoantibodies.
Conclusion
Short-term UVR exposure prior to illness onset may have a role in the clinical and serologic expression of juvenile myositis. Further research examining the mechanisms of action of UVR in the pathogenesis of juvenile IIM is suggested from these findings.
Details
- Title: Subtitle
- Ultraviolet Radiation Exposure is Associated with Clinical and Autoantibody Phenotypes in Juvenile Myositis
- Creators
- Mona Shah - Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Bethesda, MDIra N Targoff - Veteran’s Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OKMadeline M Rice - Department of Epidemiology and Biostatistics, George Washington University School of Medicine, Washington, DCFrederick W Miller - Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Bethesda, MDLisa G Rider - Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Bethesda, MDChildhood Myositis Heterogeneity Collaborative Study Group
- Contributors
- Scott A Vogelgesang (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Arthritis and rheumatism, Vol.65(7), pp.1934-1941
- DOI
- 10.1002/art.37985
- PMID
- 23658122
- PMCID
- PMC3727975
- NLM abbreviation
- Arthritis Rheum
- ISSN
- 0004-3591
- eISSN
- 1529-0131
- Publisher
- Wiley
- Grant note
- Z99 ES999999 || ES / National Institute of Environmental Health Sciences : NIEHS
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Immunology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984094501102771
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