Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy

Pedro M. Pimentel-Coelho; Paulo H. Rosado-de-Castro; Lea M. Barbosa da Fonseca; Rosalia Mendez-Otero

doi:10.1038/pr.2011.59

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Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy

Journal article

Open access

Peer reviewed

Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy

Pedro M. Pimentel-Coelho, Paulo H. Rosado-de-Castro, Lea M. Barbosa da Fonseca and Rosalia Mendez-Otero

Pediatric research, Vol.71(4), pp.464-473

04/01/2012

DOI: 10.1038/pr.2011.59

PMID: 22430382

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Abstract

Despite recent advances in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) using therapeutic hypothermia, at least 30% of the cooled infants will die or have moderate/severe neurological disability. Umbilical cord blood cells (UCBCs), which are readily available at birth, have been shown to reduce sensorimotor and/or cognitive impairments in several models of brain damage, representing a promising option for the treatment of neurological diseases. In this review, we discuss recent preclinical studies that assessed the effects of UCBC transplantation in the Rice-Vannucci animal model of HIE. We also review the possible cell types and mechanisms involved in the therapeutic effect of UCBC transplantation, including neuroprotection, immunomodulation, and stimulation of neural plasticity and regeneration. In addition, we discuss how neuroimaging methods, such as bioluminescence imaging, nuclear-medicine imaging, or magnetic resonance imaging, could be used to evaluate the biodistribution of UCBCs in both preclinical and clinical studies.

Life Sciences & Biomedicine

Pediatrics

Science & Technology

Details

Title: Subtitle: Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy
Creators: Pedro M. Pimentel-Coelho - Universidade Federal do Rio de Janeiro
Paulo H. Rosado-de-Castro - Hospital Universitário Clementino Fraga Filho
Lea M. Barbosa da Fonseca - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, Rio De Janeiro, Brazil
Rosalia Mendez-Otero - Universidade Federal do Rio de Janeiro
Resource Type: Journal article
Publication Details: Pediatric research, Vol.71(4), pp.464-473
DOI: 10.1038/pr.2011.59
PMID: 22430382
NLM abbreviation: Pediatr Res
ISSN: 0031-3998
eISSN: 1530-0447
Publisher: Springer Nature
Number of pages: 10
Grant note: FAPERJ; Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) CAPES; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Language: English
Date published: 04/01/2012
Academic Unit: Radiology
Record Identifier: 9985143553202771

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