Journal article
Unbound vitamin D concentrations are not decreased in critically ill patients
Internal medicine journal, Vol.52(1), pp.89-94
01/2022
DOI: 10.1111/imj.15096
PMID: 33040415
Abstract
Free concentrations of highly protein bound hormones, such as cortisol and thyroxine, are unchanged in critical illness despite substantial decreases in total concentration. Total 25-hydroxyvitamin D (25(OH)D) concentration is decreased in critical illness, but the free concentration of 25(OH)D has had less attention.
To compare total and calculated free 25(OH)D concentrations in critically ill patients with healthy controls.
In this case-control study, 38 patients with critical illness were compared with 68 healthy controls; 25(OH)D was measured by liquid chromatography tandem mass spectrometry (LCMS/MS) and vitamin D binding protein (VDBP) by direct sandwich enzyme-linked immunosorbent assay. Total and calculated free 25(OH)D concentrations were compared using unpaired t-tests.
Total 25(OH)D concentrations were significantly lower in critically ill patients than controls (37 (95% confidence interval 31-43) vs 57 (53-60) nmol/L). Calculated free concentrations of 25(OH)D were not lower in critically ill patients than healthy controls (26 (22-29) vs 19 (18-20) pmol/L).
Calculated free 25(OH)D concentrations are not decreased in critical illness. Measuring total 25(OH)D concentrations in patients with critical illness potentially underestimates vitamin D and overestimates the number of patients who are deficient in vitamin D.
Details
- Title: Subtitle
- Unbound vitamin D concentrations are not decreased in critically ill patients
- Creators
- David Palmer - Canterbury District Health BoardSteven Soule - Canterbury District Health BoardRavinder R Gaddam - University of OtagoPeter Elder - University of OtagoStephen Chambers - University of OtagoMatthew Doogue - Canterbury District Health Board
- Resource Type
- Journal article
- Publication Details
- Internal medicine journal, Vol.52(1), pp.89-94
- DOI
- 10.1111/imj.15096
- PMID
- 33040415
- ISSN
- 1444-0903
- eISSN
- 1445-5994
- Language
- English
- Date published
- 01/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984446442202771
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