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Understanding Changing Risk Factor Associations With Increasing Age in Adults
Journal article   Open access   Peer reviewed

Understanding Changing Risk Factor Associations With Increasing Age in Adults

G. A. Kaplan, Mary N. Haan and Robert B. Wallace
Annual review of public health, Vol.20(1), pp.89-108
05/1999
DOI: 10.1146/annurev.publhealth.20.1.89
PMID: 10352851
url
https://doi.org/10.1146/annurev.publhealth.20.1.89View
Published (Version of record) Open Access

Abstract

▪ Abstract  With an increasingly older population, there is considerable interest in understanding the potential for risk factor interventions in order to prevent, postpone, or slow down the common diseases seen in older persons. However, it is often reported that the strength of association between risk factors and common disease outcomes decreases with increasing age. Actually, many different age-related patterns are observed. Understanding these patterns requires knowledge of issues related to the pathophysiology of aging, including age-related physiologic and metabolic alterations, detection and diagnosis of disease in the elderly, measurement of risk factors, sample selection, comorbidity, competing risks, selective survival, ceiling effects, and methods of analysis in aging populations.

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