Journal article
Understanding the Tabletability Differences between Indomethacin Polymorphs Using Powder Brillouin Light Scattering
Pharmaceutical research, Vol.36(10), pp.150-11
10/01/2019
DOI: 10.1007/s11095-019-2681-9
PMID: 31428879
Abstract
Purpose The unconventional tabletability of the indomethacin polymorphs - alpha and gamma - are investigated from a topological and mechanical perspective using powder Brillouin light scattering (p-BLS) to identify the specific structure-performance relationship in these materials. Method Indomethacin (gamma-form) was purchased and used to prepare the alpha polymorph. Powder X-ray diffraction was used to confirm phase identity, while p-BLS was used to obtain the mechanical properties. Energy frameworks were determined with Crystal Explorer to visualize the interaction topologies. Using a Carver press and a stress-strain analyzer, the tableting performance of each polymorph was determined. Results Polymorph-specific acoustic frequency distributions were observed with distinct, zero-porosity, aggregate elastic moduli determined. The p-BLS spectra for alpha-indomethacin display a population of low-velocity shear modes, indicating a direction of facilitated shear. This improves slip-mediated plasticity and tabletability. Our p-BLS spectra experimentally indicates that a low-energy slip system is available to alpha-indomethacin which supports ours and previous energy framework calculations. Despite a 2d-layered crystal motif favorable for shear deformation, the gamma-form displays a higher shear modulus that is supported by our hydrogen-bonding analysis of gamma-indomethacin. Conclusion Our experimental, mechanical data is consistent with the predicted interaction topologies and these two inputs combined permit a comprehensive, molecular understanding of polymorph-specific tabletability.
Details
- Title: Subtitle
- Understanding the Tabletability Differences between Indomethacin Polymorphs Using Powder Brillouin Light Scattering
- Creators
- Beth A. Young - University of IowaDherya Bahl - University of IowaLewis L. Stevens - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pharmaceutical research, Vol.36(10), pp.150-11
- Publisher
- Springer Nature
- DOI
- 10.1007/s11095-019-2681-9
- PMID
- 31428879
- ISSN
- 0724-8741
- eISSN
- 1573-904X
- Number of pages
- 11
- Grant note
- Terrence and Donna Dahl Pharmaceutics Fellowship
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984366017902771
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