Understanding the coronary circulation through studies at the microvascular level

Melvin L Marcus; William M Chilian; Hiroshi Kanatsuka; Kevin C Dellsperger; Charles L Eastham; Kathryn G Lamping

doi:10.1161/01.CIR.82.1.1

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Understanding the coronary circulation through studies at the microvascular level

Journal article

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Peer reviewed

Understanding the coronary circulation through studies at the microvascular level

Melvin L Marcus, William M Chilian, Hiroshi Kanatsuka, Kevin C Dellsperger, Charles L Eastham and Kathryn G Lamping

Circulation (New York, N.Y.), Vol.82(1), pp.1-7

1990

DOI: 10.1161/01.CIR.82.1.1

PMID: 2114232

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Abstract

Studies of the coronary circulation have divided vascular resistances into three large components: large vessels, small resistance vessels, and veins. Studies of the epicardial microcirculation in the beating heart using stroboscopic illumination have suggested that resistance is more precisely controlled in different segments of the circulation. Measurements of coronary pressure in different sized arteries and arterioles have indicated that under normal conditions, 45-50% of total coronary vascular resistance resides in vessels larger than 100 microns. This distribution of vascular resistance can be altered in a nonuniform manner by a variety of physiological (autoregulation, increases in myocardial oxygen consumption, sympathetic stimulation) and pharmacological stimuli (norepinephrine, papaverine, dipyridamole, serotonin, vasopressin, nitroglycerin, adenosine, and endothelin). Studies of exchange of macromolecules in the microcirculation using fluorescent-labeled dextrans have also identified the size of the small pore (35-50 A) in coronary microvessels that can be altered by myocardial ischemia. Studies of the coronary microcirculation have demonstrated that the control of vascular resistance is extremely complex, and mechanisms responsible for these heterogeneous responses need further examination.

Cardiology. Vascular system

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: Understanding the coronary circulation through studies at the microvascular level
Creators: Melvin L Marcus - University of Iowa
William M Chilian - Univ. Iowa, cardiovascular cent., dep. internal medicine, Iowa City IA 52242, United States
Hiroshi Kanatsuka - Univ. Iowa, cardiovascular cent., dep. internal medicine, Iowa City IA 52242, United States
Kevin C Dellsperger - Univ. Iowa, cardiovascular cent., dep. internal medicine, Iowa City IA 52242, United States
Charles L Eastham - Univ. Iowa, cardiovascular cent., dep. internal medicine, Iowa City IA 52242, United States
Kathryn G Lamping - Univ. Iowa, cardiovascular cent., dep. internal medicine, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: Circulation (New York, N.Y.), Vol.82(1), pp.1-7
DOI: 10.1161/01.CIR.82.1.1
PMID: 2114232
NLM abbreviation: Circulation
ISSN: 0009-7322
eISSN: 1524-4539
Publisher: Lippincott Williams & Wilkins
Language: English
Date published: 1990
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984094486402771

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