Journal article
Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature
Pediatric transplantation, Vol.27(8), e14597
12/2023
DOI: 10.1111/petr.14597
PMCID: PMC11034761
PMID: 37664967
Appears in UI Libraries Support Open Access
Abstract
Background
Chronic kidney disease (CKD) is a relatively rare childhood disease that is associated with a wide array of medical comorbidities. Roughly half of all pediatric patients acquire CKD due to congenital anomalies of the kidneys and urinary tract, and of those with congenital disease, 50% will progress to end-stage kidney disease (ESKD) necessitating a kidney transplantation. The medical sequelae of advanced CKD/ESKD improve dramatically following successful kidney transplantation; however, the impact of kidney transplantation on neurocognition in children is less clear. It is generally thought that cognition improves following kidney transplantation; however, our knowledge on this topic is limited by the sparsity of high-quality data in the context of the relative rarity of pediatric CKD/ESKD.
Method
We conducted a narrative review to gauge the scope of the literature, using the PubMed database and the following keywords: cognition, kidney, brain, pediatric, neurocognition, intelligence, executive function, transplant, immunosuppression, and neuroimaging.
Results
There are few published longitudinal studies, and existing work often includes wide heterogeneity in age at transplant, variable dialysis exposure/duration prior to transplant, and unaccounted cofounders which persist following transplantation, including socio-economic status. Furthermore, the impact of long-term maintenance immunosuppression on the brain and cognitive function of pediatric kidney transplant (KT) recipients remains unknown.
Conclusion
In this educational review, we highlight what is known on the topic of neurocognition and neuroimaging in the pediatric KT population.
Details
- Title: Subtitle
- Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature
- Creators
- Olivia Lullmann - University of IowaEllen van der Plas - Arkansas Children's HospitalLyndsay A Harshman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric transplantation, Vol.27(8), e14597
- DOI
- 10.1111/petr.14597
- PMID
- 37664967
- PMCID
- PMC11034761
- NLM abbreviation
- Pediatr Transplant
- eISSN
- 1399-3046
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/100000054, name: National Cancer Institute; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases
- Language
- English
- Electronic publication date
- 09/04/2023
- Date published
- 12/2023
- Academic Unit
- Psychiatry; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984461801702771
Metrics
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