Journal article
Unexpected doxorubicin-induced cardiomyopathy in sisters
International cancer conference journal, Vol.1(1), pp.15-18
03/01/2012
DOI: 10.1007/s13691-011-0001-2
Abstract
We report the details of two unexpected cases of doxorubicin (DOX)-induced cardiac toxicity in two sisters receiving adjuvant breast cancer therapy. One at age 38 developed a cardiomyopathy resulting in cardiac transplantation 6.5 years after receiving a relatively low total dose of DOX, i.e., 280 mg/m
2
. The second at age 60 also developed a severe cardiomyopathy (i.e., a ventricular ejection fraction of 22%) 6 years after receiving a total dose of DOX of only 158 mg/m
2
. Twelve single nucleotide polymorphisms previously associated with doxorubicin cardiotoxicity were assessed by pyrosequencing. None of the genotypes associated with an increased risk of doxorubicin-induced cardiotoxicity were identified in these two patients.
Details
- Title: Subtitle
- Unexpected doxorubicin-induced cardiomyopathy in sisters
- Creators
- Arlene A. Gayle - UW Health University HospitalKamakshi Sachidanandam - UW Health University HospitalJill Kolesar - UW Health University HospitalH. Ian Robins - UW Health University Hospital
- Resource Type
- Journal article
- Publication Details
- International cancer conference journal, Vol.1(1), pp.15-18
- Publisher
- Springer Japan
- DOI
- 10.1007/s13691-011-0001-2
- ISSN
- 2192-3183
- eISSN
- 2192-3183
- Language
- English
- Date published
- 03/01/2012
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984696546302771
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