Journal article
Unfolding the mysteries of heterochromatin
Current opinion in genetics & development, Vol.8(2), pp.147-153
1998
DOI: 10.1016/S0959-437X(98)80135-4
PMID: 9610404
Abstract
The function of heterochromatin has not been well understood. Recent studies, however, demonstrate that heterochromatin is essential for proper chromosome behavior. The silencing of euchromatic genes by heterochromatin has been exploited to understand the molecular nature of heterochromatin. Mutations that either suppress or enhance gene silencing exist within chromatin structural proteins and modifying enzymes. Interactions between some of these proteins have been demonstrated, suggesting a complicated picture of heterogeneous silencing complexes that are counteracted by protein-modifying machinery.
Details
- Title: Subtitle
- Unfolding the mysteries of heterochromatin
- Creators
- Lori L Wallrath - Department of Biochemistry, 4-772 Bowen Science Building, University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in genetics & development, Vol.8(2), pp.147-153
- DOI
- 10.1016/S0959-437X(98)80135-4
- PMID
- 9610404
- NLM abbreviation
- Curr Opin Genet Dev
- ISSN
- 0959-437X
- eISSN
- 1879-0380
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 1998
- Academic Unit
- Biochemistry and Molecular Biology; University College Courses
- Record Identifier
- 9984025271502771
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