Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus

Hakim MURADOV; Vasily KEROV; Kimberly K BOYD; Nikolai O ARTEMYEV

doi:10.1016/j.visres.2008.07.006

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Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus

Journal article

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Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus

Hakim MURADOV, Vasily KEROV, Kimberly K BOYD and Nikolai O ARTEMYEV

Vision research (Oxford), Vol.48(21), pp.2302-2308

2008

DOI: 10.1016/j.visres.2008.07.006

PMCID: PMC2613798

PMID: 18687354

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https://doi.org/10.1016/j.visres.2008.07.006View

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Abstract

Lampreys represent the most primitive vertebrate class of jawless fish and serve as an evolutionary model of the vertebrate visual system. Transducin-alpha (G alpha(t)) subunits were investigated in lamprey Petromyzon marinus in order to understand the molecular origins of rod and cone photoreceptor G proteins. Two G alpha(t) subunits, G alpha(tL) and G alpha(tS), were identified in the P. marinus retina. G alpha(tL) is equally distant from cone and rod G proteins and is expressed in the lamprey's long photoreceptors. The short photoreceptor G alpha(tS) is a rod-like transducin-alpha that retains several unique features of cone transducins. Thus, the duplication of the ancestral transducin gene giving rise to rod transducins has already occurred in the last common ancestor of the jawed and jawless vertebrates.

Fundamental and applied biological sciences. Psychology

Vertebrates: nervous system and sense organs

Biological and medical sciences

Eye and associated structures. Visual pathways and centers. Vision

Details

Title: Subtitle: Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus
Creators: Hakim MURADOV - Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, United States
Vasily KEROV - Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, United States
Kimberly K BOYD - Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, United States
Nikolai O ARTEMYEV - Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Vision research (Oxford), Vol.48(21), pp.2302-2308
DOI: 10.1016/j.visres.2008.07.006
PMID: 18687354
PMCID: PMC2613798
NLM abbreviation: Vision Res
ISSN: 0042-6989
eISSN: 1878-5646
Publisher: Elsevier Science; Oxford
Language: English
Date published: 2008
Academic Unit: Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9984070458802771

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