Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin

Mara Leone; Bart H. van Oorschot; M. Reza Nejadnik; Andrea Bocchino; Matteo Rosato; Gideon Kersten; Conor O'Mahony; Joke Bouwstra; Koen van der Maaden

doi:10.3390/pharmaceutics10040211

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Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin

Journal article

Open access

Peer reviewed

Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin

Mara Leone, Bart H. van Oorschot, M. Reza Nejadnik, Andrea Bocchino, Matteo Rosato, Gideon Kersten, Conor O'Mahony, Joke Bouwstra and Koen van der Maaden

Pharmaceutics, Vol.10(4), p.211

11/01/2018

DOI: 10.3390/pharmaceutics10040211

PMCID: PMC6321443

PMID: 30388786

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Abstract

Microneedle technologies have been developed for dermal drug and vaccine delivery, including hollow-, solid-, coated-, and dissolving microneedles. Microneedles have been made in many different geometries and of many different materials, all of which may influence their skin-penetrating ability. To ensure reproducible and effective drug and vaccine delivery via microneedles, the optimal insertion parameters should be known. Therefore, a digitally-controlled microneedle applicator was developed to insert microneedles into the skin via impact insertion (velocity) or via pressing force insertion. Six microneedle arrays with different geometries and/or materials were applied onto ex vivo human skin with varying velocities or pressing forces. Penetration efficiency and delivered antigen dose into the skin after application of microneedles were determined. In general, microneedles pierced the skin more efficiently when applied by impact application as compared to application via pressing force. However, the angle of application of the applicator on the skin can affect the velocity of the impact, influencing the penetration efficiency of microneedles. Regarding the antigen delivery into the skin, the delivered dose was increasing by increasing the velocity or pressure, and thus, increasing the penetration efficiency. These data demonstrate that an applicator is an important tool to determine optimal application conditions with ex vivo human skin.

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Science & Technology

Details

Title: Subtitle: Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin
Creators: Mara Leone - Leiden University
Bart H. van Oorschot - Denssolutions (Netherlands)
M. Reza Nejadnik - Leiden University
Andrea Bocchino - University College Cork
Matteo Rosato - University College Cork
Gideon Kersten - Leiden University
Conor O'Mahony - University College Cork
Joke Bouwstra - Centre for Human Drug Research
Koen van der Maaden - Centre for Human Drug Research
Resource Type: Journal article
Publication Details: Pharmaceutics, Vol.10(4), p.211
DOI: 10.3390/pharmaceutics10040211
PMID: 30388786
PMCID: PMC6321443
NLM abbreviation: Pharmaceutics
ISSN: 1999-4923
eISSN: 1999-4923
Publisher: Mdpi
Number of pages: 18
Language: English
Date published: 11/01/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984420846502771

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