Journal article
Unmet need in Behcet's disease: most patients in routine follow-up continue to have oral ulcers
Clinical rheumatology, Vol.33(12), pp.1773-1776
12/01/2014
DOI: 10.1007/s10067-014-2585-3
PMID: 24737283
Abstract
The clinical course of Behcet's disease (BD) as a multisystemic disorder with a remitting-relapsing nature is insufficiently explored. As complete remission should be aimed in all inflammatory diseases, we investigated the frequency of complete remission in patients with BD followed in long-term, routine practice. In this retrospective study, 258 patients with BD who were regularly followed in outpatient clinics were assessed. The demographic and clinical data for active organ manifestations and treatment protocols were evaluated, and "complete remission" for this study was defined as no sign of any disease manifestation in the current visit and the preceding month. Two hundred fifty-eight patients with BD (F/M 130/128, mean age 41.1 +/- 11.5 years) were included to the study. Mucocutaneous disease was present in 48.4 % (n = 125). Mean visit number was 6.8 +/- 2.7, and mean follow-up duration was 45.8 +/- 36.5 months. Patients were clinically active in 67.2 % (n = 1,182) of the total visits (n = 1,757), which increased to 75.6 % (68.1-90.3) when the month preceding the visit was also included. The most common active manifestation was oral ulcers (39.4-63.2 %) followed by other mucocutaneous manifestations and musculoskeletal involvement. When multivariate analysis was performed, oral ulcers, which are the main cause of the clinical activity, negatively correlated with immunosuppressive treatments (beta = -0.356, p < 0.000) and age (beta = -0.183, p = 0.04). It is fairly difficult to achieve complete remission in BD with current therapeutic regimens. The reluctance of the clinician to be aggressive for some BD manifestations with low morbidity, such as mucocutaneous lesions and arthritis, might be influencing the continuous, low-disease activity state, especially due to oral ulcers, in BD patients.
Details
- Title: Subtitle
- Unmet need in Behcet's disease: most patients in routine follow-up continue to have oral ulcers
- Creators
- Fatma Alibaz-Oner - Marmara UniversityGonca Mumcu - Marmara UniversityZeynep Kubilay - Marmara UniversityGulsen Ozen - Marmara UniversityGulce Celik - Marmara UniversityAsli Karadeniz - Marmara UniversityMeryem Can - Marmara UniversitySibel Yilmaz Oner - Marmara UniversityNevsun Inanc - Marmara UniversityPamir Atagunduz - Marmara UniversityTulin Ergun - Marmara UniversityHaner Direskeneli - Marmara University
- Resource Type
- Journal article
- Publication Details
- Clinical rheumatology, Vol.33(12), pp.1773-1776
- Publisher
- Springer Nature
- DOI
- 10.1007/s10067-014-2585-3
- PMID
- 24737283
- ISSN
- 0770-3198
- eISSN
- 1434-9949
- Number of pages
- 4
- Language
- English
- Date published
- 12/01/2014
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984702943302771
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