Journal article
Unnatural Amino Acids as Probes of Ligand-Receptor Interactions and Their Conformational Consequences
Annual review of pharmacology and toxicology, Vol.53(1), pp.211-229
2013
DOI: 10.1146/annurev-pharmtox-011112-140343
PMID: 23294309
Abstract
G protein-coupled receptors and ion channels couple a wide range of external stimuli to cellular growth and division, metabolism, motility, and a myriad of intra- and intercellular signaling pathways. G protein-coupled receptors initiate complex, interrelated downstream signaling cascades, whereas rapid ionic flux through channels directly supports membrane excitability and mediates cellular functions through second messengers. Because of these characteristics, these ubiquitous transmembrane proteins are valuable therapeutic targets and have provided fertile ground for the development of leading-edge synthetic and chemical biological approaches. Here we summarize recent advances in the use of site-directed incorporation of unnatural amino acids and chemical probes to study ligand-receptor interactions, determine the location of binding sites, and examine the downstream conformational consequences of ligand binding in G protein-coupled receptors and ion channels
Details
- Title: Subtitle
- Unnatural Amino Acids as Probes of Ligand-Receptor Interactions and Their Conformational Consequences
- Creators
- Stephan A PLESS - Department of Anesthesiology, Pharmacology and Therapeutics and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, CanadaChristopher A AHERN - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- Annual review of pharmacology and toxicology, Vol.53(1), pp.211-229
- Publisher
- Annual Reviews; Palo Alto, CA
- DOI
- 10.1146/annurev-pharmtox-011112-140343
- PMID
- 23294309
- ISSN
- 0362-1642
- eISSN
- 1545-4304
- Language
- English
- Date published
- 2013
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984070546402771
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