Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model

Brian T Andrews; Scott Barbay; Jakob Townsend; Michael Detamore; Janna Harris; Chad Tuchek; Randolph J Nudo

doi:10.1038/s41598-020-79155-8

Back

Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model

Journal article

Open access

Peer reviewed

Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model

Brian T Andrews, Scott Barbay, Jakob Townsend, Michael Detamore, Janna Harris, Chad Tuchek and Randolph J Nudo

Scientific reports, Vol.10(1), pp.22242-22242

12/17/2020

DOI: 10.1038/s41598-020-79155-8

PMCID: PMC7747615

PMID: 33335178

Files and links (1)

url

https://doi.org/10.1038/s41598-020-79155-8View

Published (Version of record) Open Access

Abstract

Decompressive craniectomy (DC) is often required to manage rising intracranial pressure after traumatic brain injury (TBI). Syndrome of the trephine (SoT) is a reversible neurologic condition that often occurs following DC as a result of the unrepaired skull. The purpose of the present study is to characterize neurological impairment following TBI in rats with an unrepaired craniectomy versus rats with a closed cranium. Long Evans male rats received a controlled cortical impact (CCI) over the caudal forelimb area (CFA) of the motor cortex. Immediately after CCI, rats received either a hemi-craniectomy (TBI Open Skull Group) or an immediate acrylic cranioplasty restoring cranial anatomy (TBI Closed Skull Group). Motor performance was assessed on a skilled reaching task on post-CCI weeks 1-4, 8, 12, and 16. Three weeks after the CCI injury, the TBI Closed Skull Group demonstrated improved motor performance compared to TBI Open Skull Group. The TBI Closed Skull Group continued to perform better than the TBI Open Skull Group throughout weeks 4, 8, 12 and 16. The protracted recovery of CFA motor performance demonstrated in rats with unrepaired skulls following TBI suggests this model may be beneficial for testing new therapeutic approaches to prevent SoT.

Magnetic Resonance Imaging

Psychomotor Performance

Decompressive Craniectomy - adverse effects

Rats

Motor Cortex - physiopathology

Motor Activity

Decompressive Craniectomy - methods

Behavior, Animal

Intracranial Pressure

Brain Injuries, Traumatic - physiopathology

Brain Injuries, Traumatic - surgery

Animals

Brain Injuries, Traumatic - diagnosis

Disease Models, Animal

Details

Title: Subtitle: Unrepaired decompressive craniectomy worsens motor performance in a rat traumatic brain injury model
Creators: Brian T Andrews - Department of Plastic and Reconstructive Surgery, University of Kansas Medical Center, Sutherland Institute, MS 3015, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA. bandrews@kumc.edu
Scott Barbay - Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA
Jakob Townsend - School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA
Michael Detamore - School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA
Janna Harris - Department of Anatomy and Cell Biology, University of Kansas, Kansas City, KS, USA
Chad Tuchek - Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS, USA
Randolph J Nudo - Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA
Resource Type: Journal article
Publication Details: Scientific reports, Vol.10(1), pp.22242-22242
DOI: 10.1038/s41598-020-79155-8
PMID: 33335178
PMCID: PMC7747615
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Grant note: R03 DE025906 / NIDCR NIH HHS
Language: English
Date published: 12/17/2020
Academic Unit: Craniofacial Anomalies Research Center; Neurosurgery; Otolaryngology
Record Identifier: 9984107424302771

Metrics

18 Record Views

11 Times Cited - Web of Science