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Unresponsive Intractable Chronic Headache With Sitagliptin
Journal article   Open access   Peer reviewed

Unresponsive Intractable Chronic Headache With Sitagliptin

Ahmed Zaghloul, Corina Iorgoveanu, Andrew Polio and Aakash Desai
Curēus (Palo Alto, CA), Vol.10(4), e2537
04/25/2018
DOI: 10.7759/cureus.2537
PMID: 29946505
url
https://doi.org/10.7759/cureus.2537View
Published (Version of record) Open Access

Abstract

Sitagliptin is an anti-diabetic medication within the dipeptidyl peptidase 4 (DPP4) inhibitor class used as a single agent or in combination therapy. It is a well-studied and well-tolerated medication with commonly reported adverse events of upper respiratory tract infections, nasopharyngitis, headache, and gastrointestinal (GI) upset. Post-marketing reports have also identified associations with acute pancreatitis and joint pain. Here, we report a case of type II diabetes with chronic headache which resolved rapidly after discontinuation of sitagliptin. Our case demonstrates the need for continuous monitoring and post-marketing surveillance for drugs with tolerable side effect profile. Also, increasing patient and physician awareness of long-term side effects of these commonly used medications is essential for adequate patient safety and quality care.
Internal Medicine Neurology Endocrinology/Diabetes/Metabolism

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