Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity

Alaa A. Alkhateeb; Lloyd A. Mancl; Richard B. Presland; Marilynn L. Rothen; Donald L. Chi

doi:10.1159/000450658

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Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity

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Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity

Alaa A. Alkhateeb, Lloyd A. Mancl, Richard B. Presland, Marilynn L. Rothen and Donald L. Chi

Caries research, Vol.51(1), pp.1-6

11/16/2016

DOI: 10.1159/000450658

PMCID: PMC5337435

PMID: 27846621

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Abstract

Salivary flow rate, pH, and buffering capacity are associated with dental caries, but studies from the cystic fibrosis (CF) literature are inconclusive regarding these salivary factors and caries. The aim of this study was to evaluate these factors and their associations with dental caries in individuals with CF. Unstimulated whole saliva was collected from individuals ages 6–20 years at Seattle Children’s Hospital CF Clinic (U.S.A.) (N=83). Salivary flow rate was measured in mL/minute. Salivary pH was assessed using a laboratory pH meter. Buffering capacity was assessed by titration with HCl. The outcome measure was caries prevalence, defined as the number of decayed, missing, or filled primary and permanent tooth surfaces. Spearman’s rank correlation coefficient and the t-test were used to test for bivariate associations. Multiple variable linear regression models were used to: 1) run confounder-adjusted analyses; and 2) assess for a potential interactions. There was no significant association between salivary flow rate or buffering capacity and caries prevalence. There was a significant negative association between salivary pH and caries prevalence, but this association was no longer significant after adjusting for age. There was no significant interaction between salivary flow rate and buffering capacity or between antibiotic use and the three salivary factors. Our results indicate that unstimulated salivary factors are not associated with dental caries in individuals with CF. Future studies should investigate other potential saliva-related caries risk factors in individuals with CF such as cariogenic bacteria levels, salivary host defense peptide levels, and medication use.

buffering capacity

cystic fibrosis

dental caries

salivary flow

Unstimulated saliva

Details

Title: Subtitle: Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity
Creators: Alaa A. Alkhateeb - University of Washington
Lloyd A. Mancl - University of Washington School of Medicine
Richard B. Presland - University of Washington School of Medicine
Marilynn L. Rothen - University of Washington School of Medicine
Donald L. Chi - University of Washington School of Medicine
Resource Type: Journal article
Publication Details: Caries research, Vol.51(1), pp.1-6
DOI: 10.1159/000450658
PMID: 27846621
PMCID: PMC5337435
NLM abbreviation: Caries Res
ISSN: 0008-6568
eISSN: 1421-976X
Language: English
Date published: 11/16/2016
Academic Unit: Public Policy Center (Archive)
Record Identifier: 9984283706302771

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