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Unsuccessful transscleral cyclophotocoagulation in oculocutaneous albinism
Journal article   Open access   Peer reviewed

Unsuccessful transscleral cyclophotocoagulation in oculocutaneous albinism

Aaron D. Dotson, John H. Fingert and Erin A. Boese
American journal of ophthalmology case reports, Vol.34, 102020
06/2024
DOI: 10.1016/j.ajoc.2024.102020
PMCID: PMC10884796
PMID: 38404485
url
https://doi.org/10.1016/j.ajoc.2024.102020View
Published (Version of record) Open Access

Abstract

To report a case of unsuccessful transscleral cyclophotocoagulation in a patient with OCA1A tyrosinase-negative oculocutaneous albinism. A 35-year-old Asian female with molecularly diagnosed OCA1A (tyrosinase-negative) oculocutaneous albinism and unilateral severe mixed mechanism glaucoma underwent transscleral cyclophotocoagulation on two separate occasions to treat elevated intraocular pressure. The intraocular pressure remained markedly elevated approximately 1 month following two separate treatments of transscleral cyclophotocoagulation while using high energy settings. The poor efficacy of both cyclophotocoagulation treatments was most likely due to a lack of melanin in the setting of oculocutaneous albinism. Cyclophotocoagulation in patients with oculocutaneous albinism is less likely to yield a desired lowering of intraocular pressure due to the absence of melanin.
Cyclophotocoagulation Glaucoma Oculocutaneous albinism

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